Outcome measures in spinal cord injury: recent assessments and recommendations for future directions

M S Alexander; K D Anderson; F Biering-Sorensen; A R Blight; R Brannon; T N Bryce; G Creasey; A Catz; A Curt; W Donovan; J Ditunno; P Ellaway; N B Finnerup; D E Graves; B A Haynes; A W Heinemann; A B Jackson; M V Johnston; C Z Kalpakjian; N Kleitman; A Krassioukov; K Krogh; D Lammertse; S Magasi; M J Mulcahey; B Schurch; A Sherwood; J D Steeves; S Stiens; D S Tulsky; H J A van Hedel; G Whiteneck

doi:10.1038/sc.2009.18

Outcome measures in spinal cord injury: recent assessments and recommendations for future directions

M S Alexander, K D Anderson, F Biering-Sorensen, A R Blight, R Brannon, T N Bryce, G Creasey, A Catz, A Curt, W Donovan, J Ditunno, P Ellaway, N B Finnerup, D E Graves, B A Haynes, A W Heinemann, A B Jackson, M V Johnston, C Z Kalpakjian, N KleitmanA Krassioukov, K Krogh, D Lammertse, S Magasi, M J Mulcahey, B Schurch, A Sherwood, J D Steeves, S Stiens, D S Tulsky, H J A van Hedel, G Whiteneck

Department of Brain and Spinal Cord Injury

Abstract

STUDY DESIGN: Review by the spinal cord outcomes partnership endeavor (SCOPE), which is a broad-based international consortium of scientists and clinical researchers representing academic institutions, industry, government agencies, not-for-profit organizations and foundations.

OBJECTIVES: Assessment of current and evolving tools for evaluating human spinal cord injury (SCI) outcomes for both clinical diagnosis and clinical research studies.

METHODS: a framework for the appraisal of evidence of metric properties was used to examine outcome tools or tests for accuracy, sensitivity, reliability and validity for human SCI.

RESULTS: Imaging, neurological, functional, autonomic, sexual health, bladder/bowel, pain and psychosocial tools were evaluated. Several specific tools for human SCI studies have or are being developed to allow the more accurate determination for a clinically meaningful benefit (improvement in functional outcome or quality of life) being achieved as a result of a therapeutic intervention.

CONCLUSION: Significant progress has been made, but further validation studies are required to identify the most appropriate tools for specific targets in a human SCI study or clinical trial.

Original language	English
Journal	Spinal Cord
Volume	47
Issue number	8
Pages (from-to)	582-91
Number of pages	10
ISSN	1362-4393
DOIs	https://doi.org/10.1038/sc.2009.18
Publication status	Published - Aug 2009

Keywords

Clinical Trials as Topic/methods
Humans
Outcome Assessment, Health Care/methods
Spinal Cord Injuries/diagnosis
Treatment Outcome

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10.1038/sc.2009.18

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Alexander, M. S., Anderson, K. D., Biering-Sorensen, F., Blight, A. R., Brannon, R., Bryce, T. N., Creasey, G., Catz, A., Curt, A., Donovan, W., Ditunno, J., Ellaway, P., Finnerup, N. B., Graves, D. E., Haynes, B. A., Heinemann, A. W., Jackson, A. B., Johnston, M. V., Kalpakjian, C. Z., ... Whiteneck, G. (2009). Outcome measures in spinal cord injury: recent assessments and recommendations for future directions. Spinal Cord, 47(8), 582-91. https://doi.org/10.1038/sc.2009.18

Alexander, MS, Anderson, KD, Biering-Sorensen, F, Blight, AR, Brannon, R, Bryce, TN, Creasey, G, Catz, A, Curt, A, Donovan, W, Ditunno, J, Ellaway, P, Finnerup, NB, Graves, DE, Haynes, BA, Heinemann, AW, Jackson, AB, Johnston, MV, Kalpakjian, CZ, Kleitman, N, Krassioukov, A, Krogh, K, Lammertse, D, Magasi, S, Mulcahey, MJ, Schurch, B, Sherwood, A, Steeves, JD, Stiens, S, Tulsky, DS, van Hedel, HJA & Whiteneck, G 2009, 'Outcome measures in spinal cord injury: recent assessments and recommendations for future directions', Spinal Cord, vol. 47, no. 8, pp. 582-91. https://doi.org/10.1038/sc.2009.18

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abstract = "STUDY DESIGN: Review by the spinal cord outcomes partnership endeavor (SCOPE), which is a broad-based international consortium of scientists and clinical researchers representing academic institutions, industry, government agencies, not-for-profit organizations and foundations.OBJECTIVES: Assessment of current and evolving tools for evaluating human spinal cord injury (SCI) outcomes for both clinical diagnosis and clinical research studies.METHODS: a framework for the appraisal of evidence of metric properties was used to examine outcome tools or tests for accuracy, sensitivity, reliability and validity for human SCI.RESULTS: Imaging, neurological, functional, autonomic, sexual health, bladder/bowel, pain and psychosocial tools were evaluated. Several specific tools for human SCI studies have or are being developed to allow the more accurate determination for a clinically meaningful benefit (improvement in functional outcome or quality of life) being achieved as a result of a therapeutic intervention.CONCLUSION: Significant progress has been made, but further validation studies are required to identify the most appropriate tools for specific targets in a human SCI study or clinical trial.",

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AU - Brannon, R

AU - Bryce, T N

AU - Creasey, G

AU - Catz, A

AU - Curt, A

AU - Donovan, W

AU - Ditunno, J

AU - Ellaway, P

AU - Finnerup, N B

AU - Graves, D E

AU - Haynes, B A

AU - Heinemann, A W

AU - Jackson, A B

AU - Johnston, M V

AU - Kalpakjian, C Z

AU - Kleitman, N

AU - Krassioukov, A

AU - Krogh, K

AU - Lammertse, D

AU - Magasi, S

AU - Mulcahey, M J

AU - Schurch, B

AU - Sherwood, A

AU - Steeves, J D

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Outcome measures in spinal cord injury: recent assessments and recommendations for future directions

Abstract

Keywords

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