Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Outcome in patients with isolated regional recurrence after primary radiotherapy for head and neck cancer

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Reply to Letter to the Editor regarding "Elective neck dissection and its extent in Salivary gland cancers: A Dilemma"

    Research output: Contribution to journalLetterResearchpeer-review

  2. Prognostic scoring models in parotid gland carcinoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Surgical treatment of the neck in patients with salivary gland carcinoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Ultrasound-guided fine-needle aspiration biopsy of thyroid nodules

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Impact of human papillomavirus in sinonasal cancer-a systematic review

    Research output: Contribution to journalReviewResearchpeer-review

  2. Systemic Immune Profile in Patients With CRSwNP

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Methods for collecting upper respiratory tract specimens for COVID-19 diagnostics

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

BACKGROUND: Isolated regional recurrences following head-neck squamous-cell carcinomas (HNSCC) are often accessible for curatively intended salvage treatment. Factors prognostic for outcome were investigated in a large cohort of HNSCC patients.

METHODS: In total, 1811 patients receiving curatively intended radiotherapy from 2007 to 2017 were reviewed and isolated cervical nodal recurrences were identified. Factors associated with survival and second recurrence were investigated using univariate and multivariate analyses.

RESULTS: Isolated regional recurrence was seen in 95/1811 (5.2%) patients. Eighty of 95 patients (84%) received salvage surgery. Two-year survival after isolated regional recurrence was 40%. Overall survival (OS) and time to second recurrence were associated with resection status of the salvage surgery and presence of extranodal spread (ENS), while p16-positive oropharyngeal squamous-cell carcinoma (OPSCC) was associated with better OS.

CONCLUSION: Long-term survival after regional recurrence in HNSCC is possible. p16-positive OPSCC, complete salvage surgery, and lack of ENS are associated with better outcome.

Original languageEnglish
JournalHead and Neck
Volume42
Issue number11
Pages (from-to)3161-3170
Number of pages10
ISSN1043-3074
DOIs
Publication statusPublished - 1 Nov 2020

    Research areas

  • head and neck cancer, prognostic factors, recurrence, salvage treatment, survival

ID: 60986039