Outcome in patients with isolated regional recurrence after primary radiotherapy for head and neck cancer

Anne Marie Lindegaard; Christian von Buchwald; Jacob H Rasmussen; Lena Specht; Ivan R Vogelius; Martin Zamani; Nina Claire Woller; Giedrius Lelkaitis; Jeppe Friborg

doi:10.1002/hed.26361

Outcome in patients with isolated regional recurrence after primary radiotherapy for head and neck cancer

Anne Marie Lindegaard, Christian von Buchwald, Jacob H Rasmussen, Lena Specht, Ivan R Vogelius, Martin Zamani, Nina Claire Woller, Giedrius Lelkaitis, Jeppe Friborg

8 Citations (Scopus)

Abstract

BACKGROUND: Isolated regional recurrences following head-neck squamous-cell carcinomas (HNSCC) are often accessible for curatively intended salvage treatment. Factors prognostic for outcome were investigated in a large cohort of HNSCC patients.

METHODS: In total, 1811 patients receiving curatively intended radiotherapy from 2007 to 2017 were reviewed and isolated cervical nodal recurrences were identified. Factors associated with survival and second recurrence were investigated using univariate and multivariate analyses.

RESULTS: Isolated regional recurrence was seen in 95/1811 (5.2%) patients. Eighty of 95 patients (84%) received salvage surgery. Two-year survival after isolated regional recurrence was 40%. Overall survival (OS) and time to second recurrence were associated with resection status of the salvage surgery and presence of extranodal spread (ENS), while p16-positive oropharyngeal squamous-cell carcinoma (OPSCC) was associated with better OS.

CONCLUSION: Long-term survival after regional recurrence in HNSCC is possible. p16-positive OPSCC, complete salvage surgery, and lack of ENS are associated with better outcome.

Original language	English
Journal	Head and Neck
Volume	42
Issue number	11
Pages (from-to)	3161-3170
Number of pages	10
ISSN	1043-3074
DOIs	https://doi.org/10.1002/hed.26361
Publication status	Published - 1 Nov 2020

Keywords

head and neck cancer
prognostic factors
recurrence
salvage treatment
survival

Access to Document

10.1002/hed.26361

Cite this

@article{0ef20427daff4510b0896b1f979e7970,

title = "Outcome in patients with isolated regional recurrence after primary radiotherapy for head and neck cancer",

abstract = "BACKGROUND: Isolated regional recurrences following head-neck squamous-cell carcinomas (HNSCC) are often accessible for curatively intended salvage treatment. Factors prognostic for outcome were investigated in a large cohort of HNSCC patients.METHODS: In total, 1811 patients receiving curatively intended radiotherapy from 2007 to 2017 were reviewed and isolated cervical nodal recurrences were identified. Factors associated with survival and second recurrence were investigated using univariate and multivariate analyses.RESULTS: Isolated regional recurrence was seen in 95/1811 (5.2%) patients. Eighty of 95 patients (84%) received salvage surgery. Two-year survival after isolated regional recurrence was 40%. Overall survival (OS) and time to second recurrence were associated with resection status of the salvage surgery and presence of extranodal spread (ENS), while p16-positive oropharyngeal squamous-cell carcinoma (OPSCC) was associated with better OS.CONCLUSION: Long-term survival after regional recurrence in HNSCC is possible. p16-positive OPSCC, complete salvage surgery, and lack of ENS are associated with better outcome.",

keywords = "head and neck cancer, prognostic factors, recurrence, salvage treatment, survival",

author = "Lindegaard, {Anne Marie} and {von Buchwald}, Christian and Rasmussen, {Jacob H} and Lena Specht and Vogelius, {Ivan R} and Martin Zamani and Woller, {Nina Claire} and Giedrius Lelkaitis and Jeppe Friborg",

note = "{\textcopyright} 2020 Wiley Periodicals LLC.",

year = "2020",

month = nov,

day = "1",

doi = "10.1002/hed.26361",

language = "English",

volume = "42",

pages = "3161--3170",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John/Wiley & Sons, Inc. John/Wiley & Sons Ltd",

number = "11",

}

TY - JOUR

T1 - Outcome in patients with isolated regional recurrence after primary radiotherapy for head and neck cancer

AU - Lindegaard, Anne Marie

AU - von Buchwald, Christian

AU - Rasmussen, Jacob H

AU - Specht, Lena

AU - Vogelius, Ivan R

AU - Zamani, Martin

AU - Woller, Nina Claire

AU - Lelkaitis, Giedrius

AU - Friborg, Jeppe

PY - 2020/11/1

Y1 - 2020/11/1

N2 - BACKGROUND: Isolated regional recurrences following head-neck squamous-cell carcinomas (HNSCC) are often accessible for curatively intended salvage treatment. Factors prognostic for outcome were investigated in a large cohort of HNSCC patients.METHODS: In total, 1811 patients receiving curatively intended radiotherapy from 2007 to 2017 were reviewed and isolated cervical nodal recurrences were identified. Factors associated with survival and second recurrence were investigated using univariate and multivariate analyses.RESULTS: Isolated regional recurrence was seen in 95/1811 (5.2%) patients. Eighty of 95 patients (84%) received salvage surgery. Two-year survival after isolated regional recurrence was 40%. Overall survival (OS) and time to second recurrence were associated with resection status of the salvage surgery and presence of extranodal spread (ENS), while p16-positive oropharyngeal squamous-cell carcinoma (OPSCC) was associated with better OS.CONCLUSION: Long-term survival after regional recurrence in HNSCC is possible. p16-positive OPSCC, complete salvage surgery, and lack of ENS are associated with better outcome.

AB - BACKGROUND: Isolated regional recurrences following head-neck squamous-cell carcinomas (HNSCC) are often accessible for curatively intended salvage treatment. Factors prognostic for outcome were investigated in a large cohort of HNSCC patients.METHODS: In total, 1811 patients receiving curatively intended radiotherapy from 2007 to 2017 were reviewed and isolated cervical nodal recurrences were identified. Factors associated with survival and second recurrence were investigated using univariate and multivariate analyses.RESULTS: Isolated regional recurrence was seen in 95/1811 (5.2%) patients. Eighty of 95 patients (84%) received salvage surgery. Two-year survival after isolated regional recurrence was 40%. Overall survival (OS) and time to second recurrence were associated with resection status of the salvage surgery and presence of extranodal spread (ENS), while p16-positive oropharyngeal squamous-cell carcinoma (OPSCC) was associated with better OS.CONCLUSION: Long-term survival after regional recurrence in HNSCC is possible. p16-positive OPSCC, complete salvage surgery, and lack of ENS are associated with better outcome.

KW - head and neck cancer

KW - prognostic factors

KW - recurrence

KW - salvage treatment

KW - survival

UR - http://www.scopus.com/inward/record.url?scp=85087936087&partnerID=8YFLogxK

U2 - 10.1002/hed.26361

DO - 10.1002/hed.26361

M3 - Journal article

C2 - 32681703

VL - 42

SP - 3161

EP - 3170

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

IS - 11

ER -

Outcome in patients with isolated regional recurrence after primary radiotherapy for head and neck cancer

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this