Osteopontin deficiency dampens the pro-atherogenic effect of uraemia

Tanja X Pedersen; Marie Dalby Madsen; Nanna Junker; Christina Christoffersen; Jonas Vikeså; Susanne Bro; Anna Hultgårdh-Nilsson; Lars Bo Nielsen

doi:10.1093/cvr/cvt049

Osteopontin deficiency dampens the pro-atherogenic effect of uraemia

Tanja X Pedersen, Marie Dalby Madsen, Nanna Junker, Christina Christoffersen, Jonas Vikeså, Susanne Bro, Anna Hultgårdh-Nilsson, Lars Bo Nielsen

18 Citations (Scopus)

Abstract

Uraemia is a strong risk factor for cardiovascular disease. Osteopontin (OPN) is highly expressed in aortas of uraemic apolipoprotein E knockout (E KO) mice. OPN affects key atherogenic processes, i.e. inflammation and phenotypic modulation of smooth muscle cells (SMCs). We explored the role of OPN on vascular pathology in uraemic mice.

Original language	English
Journal	Cardiovascular Research
Volume	98
Issue number	3
Pages (from-to)	352-9
Number of pages	8
ISSN	0008-6363
DOIs	https://doi.org/10.1093/cvr/cvt049
Publication status	Published - 1 Jun 2013

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10.1093/cvr/cvt049

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abstract = "Uraemia is a strong risk factor for cardiovascular disease. Osteopontin (OPN) is highly expressed in aortas of uraemic apolipoprotein E knockout (E KO) mice. OPN affects key atherogenic processes, i.e. inflammation and phenotypic modulation of smooth muscle cells (SMCs). We explored the role of OPN on vascular pathology in uraemic mice.",

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AU - Pedersen, Tanja X

AU - Madsen, Marie Dalby

AU - Junker, Nanna

AU - Christoffersen, Christina

AU - Vikeså, Jonas

AU - Bro, Susanne

AU - Hultgårdh-Nilsson, Anna

AU - Nielsen, Lars Bo

PY - 2013/6/1

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N2 - Uraemia is a strong risk factor for cardiovascular disease. Osteopontin (OPN) is highly expressed in aortas of uraemic apolipoprotein E knockout (E KO) mice. OPN affects key atherogenic processes, i.e. inflammation and phenotypic modulation of smooth muscle cells (SMCs). We explored the role of OPN on vascular pathology in uraemic mice.

AB - Uraemia is a strong risk factor for cardiovascular disease. Osteopontin (OPN) is highly expressed in aortas of uraemic apolipoprotein E knockout (E KO) mice. OPN affects key atherogenic processes, i.e. inflammation and phenotypic modulation of smooth muscle cells (SMCs). We explored the role of OPN on vascular pathology in uraemic mice.

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Osteopontin deficiency dampens the pro-atherogenic effect of uraemia

Abstract

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