Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany

David A Rasko; Dale R Webster; Jason W Sahl; Ali Bashir; Nadia Boisen; Flemming Scheutz; Ellen E Paxinos; Robert Sebra; Chen-Shan Chin; Dimitris Iliopoulos; Aaron Klammer; Paul Peluso; Lawrence Lee; Andrey O Kislyuk; James Bullard; Andrew Kasarskis; Susanna Wang; John Eid; David Rank; Julia C Redman; Susan R Steyert; Jakob Frimodt-Møller; Carsten Struve; Andreas M Petersen; Karen Krogfelt; James P Nataro; Eric E Schadt; Matthew K Waldor

doi:10.1056/NEJMoa1106920

Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany

David A Rasko, Dale R Webster, Jason W Sahl, Ali Bashir, Nadia Boisen, Flemming Scheutz, Ellen E Paxinos, Robert Sebra, Chen-Shan Chin, Dimitris Iliopoulos, Aaron Klammer, Paul Peluso, Lawrence Lee, Andrey O Kislyuk, James Bullard, Andrew Kasarskis, Susanna Wang, John Eid, David Rank, Julia C RedmanSusan R Steyert, Jakob Frimodt-Møller, Carsten Struve, Andreas M Petersen, Karen Krogfelt, James P Nataro, Eric E Schadt, Matthew K Waldor

Gastrounit, Medical Division

682 Citations (Scopus)

Abstract

A large outbreak of diarrhea and the hemolytic-uremic syndrome caused by an unusual serotype of Shiga-toxin-producing Escherichia coli (O104:H4) began in Germany in May 2011. As of July 22, a large number of cases of diarrhea caused by Shiga-toxin-producing E. coli have been reported--3167 without the hemolytic-uremic syndrome (16 deaths) and 908 with the hemolytic-uremic syndrome (34 deaths)--indicating that this strain is notably more virulent than most of the Shiga-toxin-producing E. coli strains. Preliminary genetic characterization of the outbreak strain suggested that, unlike most of these strains, it should be classified within the enteroaggregative pathotype of E. coli.

Original language	English
Journal	New England Journal of Medicine
Volume	365
Issue number	8
Pages (from-to)	709-17
Number of pages	9
ISSN	0028-4793
DOIs	https://doi.org/10.1056/NEJMoa1106920
Publication status	Published - 2011

Keywords

Bacterial Typing Techniques
Base Sequence
Diarrhea
Disease Outbreaks
Escherichia coli Infections
Feces
Female
Genome, Bacterial
Germany
Hemolytic-Uremic Syndrome
Humans
Middle Aged
Phylogeny
Polymerase Chain Reaction
Sequence Analysis, DNA
Shiga-Toxigenic Escherichia coli

Access to Document

10.1056/NEJMoa1106920

Cite this

Rasko, D. A., Webster, D. R., Sahl, J. W., Bashir, A., Boisen, N., Scheutz, F., Paxinos, E. E., Sebra, R., Chin, C.-S., Iliopoulos, D., Klammer, A., Peluso, P., Lee, L., Kislyuk, A. O., Bullard, J., Kasarskis, A., Wang, S., Eid, J., Rank, D., ... Waldor, M. K. (2011). Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany. New England Journal of Medicine, 365(8), 709-17. https://doi.org/10.1056/NEJMoa1106920

Rasko, DA, Webster, DR, Sahl, JW, Bashir, A, Boisen, N, Scheutz, F, Paxinos, EE, Sebra, R, Chin, C-S, Iliopoulos, D, Klammer, A, Peluso, P, Lee, L, Kislyuk, AO, Bullard, J, Kasarskis, A, Wang, S, Eid, J, Rank, D, Redman, JC, Steyert, SR, Frimodt-Møller, J, Struve, C, Petersen, AM, Krogfelt, K, Nataro, JP, Schadt, EE & Waldor, MK 2011, 'Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany', New England Journal of Medicine, vol. 365, no. 8, pp. 709-17. https://doi.org/10.1056/NEJMoa1106920

@article{e6b38927eb334e2b8a520ce603380d5b,

title = "Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany",

abstract = "A large outbreak of diarrhea and the hemolytic-uremic syndrome caused by an unusual serotype of Shiga-toxin-producing Escherichia coli (O104:H4) began in Germany in May 2011. As of July 22, a large number of cases of diarrhea caused by Shiga-toxin-producing E. coli have been reported--3167 without the hemolytic-uremic syndrome (16 deaths) and 908 with the hemolytic-uremic syndrome (34 deaths)--indicating that this strain is notably more virulent than most of the Shiga-toxin-producing E. coli strains. Preliminary genetic characterization of the outbreak strain suggested that, unlike most of these strains, it should be classified within the enteroaggregative pathotype of E. coli.",

keywords = "Bacterial Typing Techniques, Base Sequence, Diarrhea, Disease Outbreaks, Escherichia coli Infections, Feces, Female, Genome, Bacterial, Germany, Hemolytic-Uremic Syndrome, Humans, Middle Aged, Phylogeny, Polymerase Chain Reaction, Sequence Analysis, DNA, Shiga-Toxigenic Escherichia coli",

author = "Rasko, {David A} and Webster, {Dale R} and Sahl, {Jason W} and Ali Bashir and Nadia Boisen and Flemming Scheutz and Paxinos, {Ellen E} and Robert Sebra and Chen-Shan Chin and Dimitris Iliopoulos and Aaron Klammer and Paul Peluso and Lawrence Lee and Kislyuk, {Andrey O} and James Bullard and Andrew Kasarskis and Susanna Wang and John Eid and David Rank and Redman, {Julia C} and Steyert, {Susan R} and Jakob Frimodt-M{\o}ller and Carsten Struve and Petersen, {Andreas M} and Karen Krogfelt and Nataro, {James P} and Schadt, {Eric E} and Waldor, {Matthew K}",

year = "2011",

doi = "10.1056/NEJMoa1106920",

language = "English",

volume = "365",

pages = "709--17",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachusetts Medical Society",

number = "8",

}

TY - JOUR

T1 - Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany

AU - Rasko, David A

AU - Webster, Dale R

AU - Sahl, Jason W

AU - Bashir, Ali

AU - Boisen, Nadia

AU - Scheutz, Flemming

AU - Paxinos, Ellen E

AU - Sebra, Robert

AU - Chin, Chen-Shan

AU - Iliopoulos, Dimitris

AU - Klammer, Aaron

AU - Peluso, Paul

AU - Lee, Lawrence

AU - Kislyuk, Andrey O

AU - Bullard, James

AU - Kasarskis, Andrew

AU - Wang, Susanna

AU - Eid, John

AU - Rank, David

AU - Redman, Julia C

AU - Steyert, Susan R

AU - Frimodt-Møller, Jakob

AU - Struve, Carsten

AU - Petersen, Andreas M

AU - Krogfelt, Karen

AU - Nataro, James P

AU - Schadt, Eric E

AU - Waldor, Matthew K

PY - 2011

Y1 - 2011

N2 - A large outbreak of diarrhea and the hemolytic-uremic syndrome caused by an unusual serotype of Shiga-toxin-producing Escherichia coli (O104:H4) began in Germany in May 2011. As of July 22, a large number of cases of diarrhea caused by Shiga-toxin-producing E. coli have been reported--3167 without the hemolytic-uremic syndrome (16 deaths) and 908 with the hemolytic-uremic syndrome (34 deaths)--indicating that this strain is notably more virulent than most of the Shiga-toxin-producing E. coli strains. Preliminary genetic characterization of the outbreak strain suggested that, unlike most of these strains, it should be classified within the enteroaggregative pathotype of E. coli.

AB - A large outbreak of diarrhea and the hemolytic-uremic syndrome caused by an unusual serotype of Shiga-toxin-producing Escherichia coli (O104:H4) began in Germany in May 2011. As of July 22, a large number of cases of diarrhea caused by Shiga-toxin-producing E. coli have been reported--3167 without the hemolytic-uremic syndrome (16 deaths) and 908 with the hemolytic-uremic syndrome (34 deaths)--indicating that this strain is notably more virulent than most of the Shiga-toxin-producing E. coli strains. Preliminary genetic characterization of the outbreak strain suggested that, unlike most of these strains, it should be classified within the enteroaggregative pathotype of E. coli.

KW - Bacterial Typing Techniques

KW - Base Sequence

KW - Diarrhea

KW - Disease Outbreaks

KW - Escherichia coli Infections

KW - Feces

KW - Female

KW - Genome, Bacterial

KW - Germany

KW - Hemolytic-Uremic Syndrome

KW - Humans

KW - Middle Aged

KW - Phylogeny

KW - Polymerase Chain Reaction

KW - Sequence Analysis, DNA

KW - Shiga-Toxigenic Escherichia coli

U2 - 10.1056/NEJMoa1106920

DO - 10.1056/NEJMoa1106920

M3 - Journal article

C2 - 21793740

SN - 0028-4793

VL - 365

SP - 709

EP - 717

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 8

ER -

Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany

Abstract

Keywords

Access to Document

Fingerprint

Cite this