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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Orbital lymphoma

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  1. Diagnosis of orbital mass lesions: clinical, radiological, and pathological recommendations

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  2. A review of nasal, paranasal, and skull base tumors invading the orbit

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  3. Lymphoma of the eyelid

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  4. The association between multiple sclerosis and uveitis

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  5. Malignant lymphoma of the conjunctiva

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  1. Loss of retinal tension and permanent decrease in retinal function: a new porcine model of rhegmatogenous retinal detachment

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  2. Prevalence and histopathological signatures of optic disc drusen based on microscopy of 1713 enucleated eyes

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  3. Reply: Is automated screening for DR indeed not yet ready as stated by Grauslund et al?

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  4. Morphology and evolution of the snake cornea

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  5. Periocular necrotizing soft tissue infection in Greater Copenhagen

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Orbital lymphomas constitute 50-60% of ocular adnexal lymphomas. A total of 2211 cases of orbital lymphoma with a known subtype have been reported in the last 24 years (1994-2017). The vast majority of orbital lymphomas are of B-cell origin (97%), of which extranodal marginal zone B-cell lymphoma (EMZL) (59%) is the most common subtype, followed by diffuse large B-cell lymphoma (23%), follicular lymphoma (9%), and mantle cell lymphoma (5%). Orbital lymphoma is primarily a disease of the elderly. Gender distribution varies according to lymphoma subtype. However, extranodal marginal zone B-cell lymphoma (53%) and follicular lymphoma (75%) show a female predominance, whereas diffuse large B-cell lymphoma shows an even gender distribution. Mantle cell lymphoma has a striking male predominance of 80%. The histopathological subtype and the clinical stage of the disease are the best indicators of prognosis and patient outcome. Low-grade lymphomas such as extranodal marginal zone B-cell lymphoma and FL have a good prognosis, whereas high-grade lymphomas (diffuse large B-cell lymphoma and mantle cell lymphoma) are associated with a poor prognosis. When managing solitary low-grade lymphomas, radiotherapy is the treatment of choice. Chemotherapy, with or without radiotherapy, should be chosen for disseminated and high-grade lymphomas.

Original languageEnglish
JournalSurvey of Ophthalmology
Volume64
Issue number1
Pages (from-to)45-66
Number of pages22
ISSN0039-6257
DOIs
Publication statusPublished - Jan 2019

    Research areas

  • Combined Modality Therapy, Global Health, Humans, Incidence, Lymphoma/diagnosis, Orbit/diagnostic imaging, Orbital Neoplasms/diagnosis, Survival Rate/trends, treatment, characteristics, pathology, lymphoma, survival, epidemiology, orbit

ID: 56468532