Oral hypoglycaemic agents in 118 diabetic pregnancies

E Hellmuth, P Damm, L Mølsted-Pedersen

    189 Citations (Scopus)


    AIMS: To assess maternal and neonatal complications in pregnancies of diabetic women treated with oral hypoglycaemic agents during pregnancy.

    METHODS: A cohort study including all consecutively registered, orally treated pregnant diabetic patients set in a diabetic obstetrical service at a university hospital: 50 women treated with metformin, 68 women treated with sulphonylurea during pregnancy and a reference group of 42 diabetic women treated with insulin during pregnancy.

    RESULTS: The prevalence of pre-eclampsia was significantly increased in the group of women treated with metformin compared to women treated with sulphonylurea or insulin (32 vs. 7 vs. 10%, P < 0.001). No difference in neonatal morbidity was observed between the orally treated and insulin-treated group; no cases of severe hypoglycaemia or jaundice were seen in the orally treated groups. However, in the group of women treated with metformin in the third trimester, the perinatal mortality was significantly increased compared to women not treated with metformin (11.6 vs. 1.3%, P < 0.02).

    CONCLUSION: Treatment with metformin during pregnancy was associated with increased prevalence of pre-eclampsia and a high perinatal mortality.

    Original languageEnglish
    JournalDiabetic Medicine
    Issue number7
    Pages (from-to)507-11
    Number of pages5
    Publication statusPublished - Jul 2000


    • Abruptio Placentae
    • Adult
    • Birth Weight
    • Cesarean Section
    • Cohort Studies
    • Diabetes Mellitus, Type 2
    • Diabetes, Gestational
    • Female
    • Fetal Death
    • Humans
    • Hypoglycemic Agents
    • Infant, Newborn
    • Infant, Newborn, Diseases
    • Insulin
    • Metformin
    • Morbidity
    • Pre-Eclampsia
    • Pregnancy
    • Pregnancy Outcome
    • Pregnancy in Diabetics
    • Tolbutamide
    • Comparative Study
    • Journal Article


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