Abstract
The toxicities of oral Ftorafur (1 g/m2/day 1-21) and intravenous 5-fluorouracil (5-FU) (500 mg/m2/day 1-5) were compared in a prospective randomized study in patients with colorectal cancer. The treatment courses were repeated every 6th week. Leucopenia was more common after 5-FU. Leucocyte nadir in connection with first treatment cycle was on average seen on day 15 in patients receiving 5-FU and on day 28 in patients receiving Ftorafur. Significantly more patients on 5-FU developed stomatitis. There was no difference in the number of patients with diarrhea or nausea/vomiting. Median survival and response rates were not significantly different after the two treatment schedules.
| Original language | English |
|---|---|
| Journal | Acta oncologica |
| Volume | 26 |
| Issue number | 6 |
| Pages (from-to) | 433-6 |
| Number of pages | 4 |
| ISSN | 0284-186X |
| Publication status | Published - 1987 |
Keywords
- Administration, Oral
- Adult
- Aged
- Blood Platelets
- Colonic Neoplasms
- Female
- Fluorouracil
- Humans
- Injections, Intravenous
- Leukocytes
- Male
- Middle Aged
- Random Allocation
- Rectal Neoplasms
- Retrospective Studies
- Tegafur
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