Oral fluoroquinolones and the risk of Achilles tendon rupture

Peter Vibe Rasmussen; Jarl Emanuel Strange; Anders Holt

doi:10.1016/j.jshs.2024.04.001

Oral fluoroquinolones and the risk of Achilles tendon rupture

Peter Vibe Rasmussen^*, Jarl Emanuel Strange, Anders Holt

^*Corresponding author for this work

Abstract

• Using nationwide Danish health register data, associations between fluoroquinolone use and elevated hazard rates of Achilles tendon rupture were found. • Associations were most pronounced with increasing dosage and within 30 days following fluoroquinolone use. • Despite recent findings calling the previously suggested associations between fluoroquinolones and aortic and valvular diseases into question, advised caution in relation to tendinopathies still seems relevant.

Original language	English
Journal	Journal of Sport and Health Science
Volume	13
Issue number	6
Pages (from-to)	749-750
Number of pages	2
ISSN	2095-2546
DOIs	https://doi.org/10.1016/j.jshs.2024.04.001
Publication status	Published - 2024

Keywords

Achilles Tendon/injuries
Administration, Oral
Anti-Bacterial Agents/adverse effects
Fluoroquinolones/adverse effects
Humans
Risk Factors
Rupture/chemically induced
Tendon Injuries/chemically induced

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10.1016/j.jshs.2024.04.001

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title = "Oral fluoroquinolones and the risk of Achilles tendon rupture",

abstract = "• Using nationwide Danish health register data, associations between fluoroquinolone use and elevated hazard rates of Achilles tendon rupture were found. • Associations were most pronounced with increasing dosage and within 30 days following fluoroquinolone use. • Despite recent findings calling the previously suggested associations between fluoroquinolones and aortic and valvular diseases into question, advised caution in relation to tendinopathies still seems relevant.",

keywords = "Achilles Tendon/injuries, Administration, Oral, Anti-Bacterial Agents/adverse effects, Fluoroquinolones/adverse effects, Humans, Risk Factors, Rupture/chemically induced, Tendon Injuries/chemically induced",

author = "Rasmussen, {Peter Vibe} and Strange, {Jarl Emanuel} and Anders Holt",

year = "2024",

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language = "English",

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AU - Rasmussen, Peter Vibe

AU - Strange, Jarl Emanuel

AU - Holt, Anders

PY - 2024

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N2 - • Using nationwide Danish health register data, associations between fluoroquinolone use and elevated hazard rates of Achilles tendon rupture were found. • Associations were most pronounced with increasing dosage and within 30 days following fluoroquinolone use. • Despite recent findings calling the previously suggested associations between fluoroquinolones and aortic and valvular diseases into question, advised caution in relation to tendinopathies still seems relevant.

AB - • Using nationwide Danish health register data, associations between fluoroquinolone use and elevated hazard rates of Achilles tendon rupture were found. • Associations were most pronounced with increasing dosage and within 30 days following fluoroquinolone use. • Despite recent findings calling the previously suggested associations between fluoroquinolones and aortic and valvular diseases into question, advised caution in relation to tendinopathies still seems relevant.

KW - Achilles Tendon/injuries

KW - Administration, Oral

KW - Anti-Bacterial Agents/adverse effects

KW - Fluoroquinolones/adverse effects

KW - Humans

KW - Risk Factors

KW - Rupture/chemically induced

KW - Tendon Injuries/chemically induced

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U2 - 10.1016/j.jshs.2024.04.001

DO - 10.1016/j.jshs.2024.04.001

M3 - Comment/debate

C2 - 38574888

SN - 2095-2546

VL - 13

SP - 749

EP - 750

JO - Journal of Sport and Health Science

JF - Journal of Sport and Health Science

IS - 6

ER -

Oral fluoroquinolones and the risk of Achilles tendon rupture

Abstract

Keywords

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