Oral cyclosporine A treatment is feasible after myeloablative conditioning in allogeneic hematopoietic stem cell transplantation

M Nygaard; D Hovgaard; I M Schjødt; N S Andersen; L Vindeløv; H Sengeløv

doi:10.1111/jcpt.12266

Oral cyclosporine A treatment is feasible after myeloablative conditioning in allogeneic hematopoietic stem cell transplantation

M Nygaard, D Hovgaard, I M Schjødt, N S Andersen, L Vindeløv, H Sengeløv

1 Citation (Scopus)

Abstract

WHAT IS KNOWN AND OBJECTIVE: The target level and route of administration of cyclosporine A (CsA) differ between transplantation centres. It is unclear whether oral CsA is sufficient to maintain target level of CsA.

CASE SUMMARY: We retrospectively analysed data from 48 adult patients, who underwent myeloablative hematopoietic stem cell transplantation. Twenty-one patients (44%) tolerated CsA orally throughout the transplantation period without increased incidence of acute graft versus host disease(aGVHD). Low concentration of CsA in week 2 was associated with increased incidence of aGVHD.

WHAT IS NEW AND CONCLUSION: Oral administration of CsA is safe, less time-consuming and economically advantageous. Close monitoring of CsA concentration is important.

Original language	English
Journal	Journal of Clinical Pharmacy and Therapeutics
Volume	40
Issue number	3
Pages (from-to)	358-61
Number of pages	4
ISSN	0269-4727
DOIs	https://doi.org/10.1111/jcpt.12266
Publication status	Published - Jun 2015

Keywords

Administration, Oral
Adolescent
Adult
Cyclosporine
Drug Monitoring
Female
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Humans
Immunosuppressive Agents
Incidence
Male
Middle Aged
Retrospective Studies
Transplantation Conditioning
Young Adult

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10.1111/jcpt.12266

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title = "Oral cyclosporine A treatment is feasible after myeloablative conditioning in allogeneic hematopoietic stem cell transplantation",

abstract = "WHAT IS KNOWN AND OBJECTIVE: The target level and route of administration of cyclosporine A (CsA) differ between transplantation centres. It is unclear whether oral CsA is sufficient to maintain target level of CsA.CASE SUMMARY: We retrospectively analysed data from 48 adult patients, who underwent myeloablative hematopoietic stem cell transplantation. Twenty-one patients (44%) tolerated CsA orally throughout the transplantation period without increased incidence of acute graft versus host disease(aGVHD). Low concentration of CsA in week 2 was associated with increased incidence of aGVHD.WHAT IS NEW AND CONCLUSION: Oral administration of CsA is safe, less time-consuming and economically advantageous. Close monitoring of CsA concentration is important.",

keywords = "Administration, Oral, Adolescent, Adult, Cyclosporine, Drug Monitoring, Female, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Humans, Immunosuppressive Agents, Incidence, Male, Middle Aged, Retrospective Studies, Transplantation Conditioning, Young Adult",

author = "M Nygaard and D Hovgaard and Schj{\o}dt, {I M} and Andersen, {N S} and L Vindel{\o}v and H Sengel{\o}v",

note = "{\textcopyright} 2015 John Wiley & Sons Ltd.",

year = "2015",

month = jun,

doi = "10.1111/jcpt.12266",

language = "English",

volume = "40",

pages = "358--61",

journal = "Journal of Clinical Pharmacy and Therapeutics",

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TY - JOUR

T1 - Oral cyclosporine A treatment is feasible after myeloablative conditioning in allogeneic hematopoietic stem cell transplantation

AU - Nygaard, M

AU - Hovgaard, D

AU - Schjødt, I M

AU - Andersen, N S

AU - Vindeløv, L

AU - Sengeløv, H

PY - 2015/6

Y1 - 2015/6

N2 - WHAT IS KNOWN AND OBJECTIVE: The target level and route of administration of cyclosporine A (CsA) differ between transplantation centres. It is unclear whether oral CsA is sufficient to maintain target level of CsA.CASE SUMMARY: We retrospectively analysed data from 48 adult patients, who underwent myeloablative hematopoietic stem cell transplantation. Twenty-one patients (44%) tolerated CsA orally throughout the transplantation period without increased incidence of acute graft versus host disease(aGVHD). Low concentration of CsA in week 2 was associated with increased incidence of aGVHD.WHAT IS NEW AND CONCLUSION: Oral administration of CsA is safe, less time-consuming and economically advantageous. Close monitoring of CsA concentration is important.

AB - WHAT IS KNOWN AND OBJECTIVE: The target level and route of administration of cyclosporine A (CsA) differ between transplantation centres. It is unclear whether oral CsA is sufficient to maintain target level of CsA.CASE SUMMARY: We retrospectively analysed data from 48 adult patients, who underwent myeloablative hematopoietic stem cell transplantation. Twenty-one patients (44%) tolerated CsA orally throughout the transplantation period without increased incidence of acute graft versus host disease(aGVHD). Low concentration of CsA in week 2 was associated with increased incidence of aGVHD.WHAT IS NEW AND CONCLUSION: Oral administration of CsA is safe, less time-consuming and economically advantageous. Close monitoring of CsA concentration is important.

KW - Administration, Oral

KW - Adolescent

KW - Adult

KW - Cyclosporine

KW - Drug Monitoring

KW - Female

KW - Graft vs Host Disease

KW - Hematopoietic Stem Cell Transplantation

KW - Humans

KW - Immunosuppressive Agents

KW - Incidence

KW - Male

KW - Middle Aged

KW - Retrospective Studies

KW - Transplantation Conditioning

KW - Young Adult

U2 - 10.1111/jcpt.12266

DO - 10.1111/jcpt.12266

M3 - Journal article

C2 - 25829023

SN - 0269-4727

VL - 40

SP - 358

EP - 361

JO - Journal of Clinical Pharmacy and Therapeutics

JF - Journal of Clinical Pharmacy and Therapeutics

IS - 3

ER -

Oral cyclosporine A treatment is feasible after myeloablative conditioning in allogeneic hematopoietic stem cell transplantation

Abstract

Keywords

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