Optic nerve oxygen tension: the effects of timolol and dorzolamide

Jens Folke Kiilgaard, D B Pedersen, T Eysteinsson, M la Cour, K Bang, P K Jensen, E Stefánsson

12 Citations (Scopus)


The authors have previously reported that carbonic anhydrase inhibitors such as acetazolamide and dorzolamide raise optic nerve oxygen tension (ONPO(2)) in pigs. The purpose of the present study was to investigate whether timolol, which belongs to another group of glaucoma drugs called beta blockers, has a similar effect. In addition, the effect of dorzolamide and timolol in combination was studied.
Original languageEnglish
JournalBritish Journal of Ophthalmology
Issue number2
Pages (from-to)276-9
Number of pages4
Publication statusPublished - 2004


  • Adrenergic beta-Antagonists
  • Animals
  • Antihypertensive Agents
  • Blood Pressure
  • Carbon Dioxide
  • Carbonic Anhydrase Inhibitors
  • Drug Interactions
  • Heart Rate
  • Intraocular Pressure
  • Optic Disk
  • Oxygen
  • Partial Pressure
  • Sulfonamides
  • Swine
  • Thiophenes
  • Timolol


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