Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes

R Rabøl; R Boushel; T Almdal; C N Hansen; T Ploug; S B Haugaard; C Prats; S Madsbad; F Dela

doi:10.1111/j.1463-1326.2010.01237.x

Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes

R Rabøl, R Boushel, T Almdal, C N Hansen, T Ploug, S B Haugaard, C Prats, S Madsbad, F Dela

42 Citations (Scopus)

Abstract

Skeletal muscle insulin resistance has been linked to mitochondrial dysfunction. We examined how improvements in muscular insulin sensitivity following rosiglitazone (ROSI) or pioglitazone (PIO) treatment would affect muscle mitochondrial function in patients with type 2 diabetes mellitus (T2DM).

Original language	English
Journal	Diabetic Medicine
Volume	12
Issue number	9
Pages (from-to)	806-14
Number of pages	8
ISSN	0742-3071
DOIs	https://doi.org/10.1111/j.1463-1326.2010.01237.x
Publication status	Published - 2010

Keywords

Body Mass Index
Cell Respiration
Diabetes Mellitus, Type 2
Female
Hemoglobin A, Glycosylated
Humans
Hypoglycemic Agents
Immunohistochemistry
Insulin Resistance
Male
Middle Aged
Mitochondria, Muscle
Muscle, Skeletal
Thiazolidinediones

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10.1111/j.1463-1326.2010.01237.x

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title = "Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes",

abstract = "Skeletal muscle insulin resistance has been linked to mitochondrial dysfunction. We examined how improvements in muscular insulin sensitivity following rosiglitazone (ROSI) or pioglitazone (PIO) treatment would affect muscle mitochondrial function in patients with type 2 diabetes mellitus (T2DM).",

keywords = "Body Mass Index, Cell Respiration, Diabetes Mellitus, Type 2, Female, Hemoglobin A, Glycosylated, Humans, Hypoglycemic Agents, Immunohistochemistry, Insulin Resistance, Male, Middle Aged, Mitochondria, Muscle, Muscle, Skeletal, Thiazolidinediones",

author = "R Rab{\o}l and R Boushel and T Almdal and Hansen, \{C N\} and T Ploug and Haugaard, \{S B\} and C Prats and S Madsbad and F Dela",

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doi = "10.1111/j.1463-1326.2010.01237.x",

language = "English",

volume = "12",

pages = "806--14",

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T1 - Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes

AU - Rabøl, R

AU - Boushel, R

AU - Almdal, T

AU - Hansen, C N

AU - Ploug, T

AU - Haugaard, S B

AU - Prats, C

AU - Madsbad, S

AU - Dela, F

PY - 2010

Y1 - 2010

N2 - Skeletal muscle insulin resistance has been linked to mitochondrial dysfunction. We examined how improvements in muscular insulin sensitivity following rosiglitazone (ROSI) or pioglitazone (PIO) treatment would affect muscle mitochondrial function in patients with type 2 diabetes mellitus (T2DM).

AB - Skeletal muscle insulin resistance has been linked to mitochondrial dysfunction. We examined how improvements in muscular insulin sensitivity following rosiglitazone (ROSI) or pioglitazone (PIO) treatment would affect muscle mitochondrial function in patients with type 2 diabetes mellitus (T2DM).

KW - Body Mass Index

KW - Cell Respiration

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Hemoglobin A, Glycosylated

KW - Humans

KW - Hypoglycemic Agents

KW - Immunohistochemistry

KW - Insulin Resistance

KW - Male

KW - Middle Aged

KW - Mitochondria, Muscle

KW - Muscle, Skeletal

KW - Thiazolidinediones

UR - https://www.scopus.com/pages/publications/77955042456

U2 - 10.1111/j.1463-1326.2010.01237.x

DO - 10.1111/j.1463-1326.2010.01237.x

M3 - Journal article

C2 - 20649633

SN - 0742-3071

VL - 12

SP - 806

EP - 814

JO - Diabetic Medicine

JF - Diabetic Medicine

IS - 9

ER -

Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes

Abstract

Keywords

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