OPPORTUNITY™: a large-scale randomized clinical trial of growth hormone in hemodialysis patients

Joel D Kopple; Alfred K Cheung; Jens Sandahl Christiansen; Christian Born Djurhuus; Meguid El Nahas; Bo Feldt-Rasmussen; William E Mitch; Christoph Wanner; Marie Göthberg; Talat Alp Ikizler

doi:10.1093/ndt/gfr363

OPPORTUNITY™: a large-scale randomized clinical trial of growth hormone in hemodialysis patients

Joel D Kopple, Alfred K Cheung, Jens Sandahl Christiansen, Christian Born Djurhuus, Meguid El Nahas, Bo Feldt-Rasmussen, William E Mitch, Christoph Wanner, Marie Göthberg, Talat Alp Ikizler

39 Citations (Scopus)

Abstract

Adult maintenance hemodialysis (MHD) patients experience high mortality and morbidity and poor quality of life (QoL). Markers of protein-energy wasting are associated with these poor outcomes. The OPPORTUNITY™ Trial examined whether recombinant human growth hormone (hGH) reduces mortality in hypoalbuminemic MHD patients. Secondary end points were effects on number of hospitalizations, cardiovascular events, lean body mass (LBM), serum proteins, exercise capacity, QoL and adverse events.

Original language	English
Journal	Nephrology, Dialysis, Transplantation
Volume	26
Issue number	12
Pages (from-to)	4095-103
Number of pages	9
ISSN	0931-0509
DOIs	https://doi.org/10.1093/ndt/gfr363
Publication status	Published - 2011

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title = "OPPORTUNITY{\texttrademark}: a large-scale randomized clinical trial of growth hormone in hemodialysis patients",

abstract = "Adult maintenance hemodialysis (MHD) patients experience high mortality and morbidity and poor quality of life (QoL). Markers of protein-energy wasting are associated with these poor outcomes. The OPPORTUNITY{\texttrademark} Trial examined whether recombinant human growth hormone (hGH) reduces mortality in hypoalbuminemic MHD patients. Secondary end points were effects on number of hospitalizations, cardiovascular events, lean body mass (LBM), serum proteins, exercise capacity, QoL and adverse events.",

author = "Kopple, \{Joel D\} and Cheung, \{Alfred K\} and Christiansen, \{Jens Sandahl\} and Djurhuus, \{Christian Born\} and \{El Nahas\}, Meguid and Bo Feldt-Rasmussen and Mitch, \{William E\} and Christoph Wanner and Marie G{\"o}thberg and Ikizler, \{Talat Alp\}",

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AU - Kopple, Joel D

AU - Cheung, Alfred K

AU - Christiansen, Jens Sandahl

AU - Djurhuus, Christian Born

AU - El Nahas, Meguid

AU - Feldt-Rasmussen, Bo

AU - Mitch, William E

AU - Wanner, Christoph

AU - Göthberg, Marie

AU - Ikizler, Talat Alp

PY - 2011

Y1 - 2011

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AB - Adult maintenance hemodialysis (MHD) patients experience high mortality and morbidity and poor quality of life (QoL). Markers of protein-energy wasting are associated with these poor outcomes. The OPPORTUNITY™ Trial examined whether recombinant human growth hormone (hGH) reduces mortality in hypoalbuminemic MHD patients. Secondary end points were effects on number of hospitalizations, cardiovascular events, lean body mass (LBM), serum proteins, exercise capacity, QoL and adverse events.

UR - https://www.scopus.com/pages/publications/82255164263

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DO - 10.1093/ndt/gfr363

M3 - Journal article

C2 - 21750157

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JO - Nephrology, Dialysis, Transplantation

JF - Nephrology, Dialysis, Transplantation

IS - 12

ER -

OPPORTUNITY™: a large-scale randomized clinical trial of growth hormone in hemodialysis patients

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