Opioider påvirker immunsystemet

Svend Gundestrup; Per Sjøgren

Opioider påvirker immunsystemet

Translated title of the contribution: Opioids can modulate the immune system

Svend Gundestrup, Per Sjøgren

Department of Anaesthesiology

2 Citations (Scopus)

Abstract

Opioids can modulate and suppress the immune system through central mediated mechanisms. Morphine increases replication and spread of HIV-1. Evidence suggests that morphine can also enhance growth and spread of some cancer diagnoses like breast-, prostate- and non-small cell lung cancer. The mechanisms behind the effects of morphine are mainly mediated by inhibiting apoptosis of cancer cells and by stimulation of angiogenesis. Some other opioid agonists seem to be depleted from these effects. Prospective studies are needed to clarify the immunosuppressive effects of opioids in cancer pain management.

Translated title of the contribution	Opioids can modulate the immune system
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	176
Issue number	24
Pages (from-to)	2261-64
ISSN	0041-5782
Publication status	Published - 2014

Cite this

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title = "Opioider p{\aa}virker immunsystemet",

abstract = "Opioids can modulate and suppress the immune system through central mediated mechanisms. Morphine increases replication and spread of HIV-1. Evidence suggests that morphine can also enhance growth and spread of some cancer diagnoses like breast-, prostate- and non-small cell lung cancer. The mechanisms behind the effects of morphine are mainly mediated by inhibiting apoptosis of cancer cells and by stimulation of angiogenesis. Some other opioid agonists seem to be depleted from these effects. Prospective studies are needed to clarify the immunosuppressive effects of opioids in cancer pain management.",

author = "Svend Gundestrup and Per Sj{\o}gren",

year = "2014",

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T1 - Opioider påvirker immunsystemet

AU - Gundestrup, Svend

AU - Sjøgren, Per

PY - 2014

Y1 - 2014

N2 - Opioids can modulate and suppress the immune system through central mediated mechanisms. Morphine increases replication and spread of HIV-1. Evidence suggests that morphine can also enhance growth and spread of some cancer diagnoses like breast-, prostate- and non-small cell lung cancer. The mechanisms behind the effects of morphine are mainly mediated by inhibiting apoptosis of cancer cells and by stimulation of angiogenesis. Some other opioid agonists seem to be depleted from these effects. Prospective studies are needed to clarify the immunosuppressive effects of opioids in cancer pain management.

AB - Opioids can modulate and suppress the immune system through central mediated mechanisms. Morphine increases replication and spread of HIV-1. Evidence suggests that morphine can also enhance growth and spread of some cancer diagnoses like breast-, prostate- and non-small cell lung cancer. The mechanisms behind the effects of morphine are mainly mediated by inhibiting apoptosis of cancer cells and by stimulation of angiogenesis. Some other opioid agonists seem to be depleted from these effects. Prospective studies are needed to clarify the immunosuppressive effects of opioids in cancer pain management.

UR - https://www.scopus.com/pages/publications/84989195909

M3 - Tidsskriftartikel

C2 - 25347334

SN - 0041-5782

VL - 176

SP - 2261

EP - 2264

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 24

ER -

Opioider påvirker immunsystemet

Abstract

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