Opioider mod refraktær dyspnø i palliativ fase

Birgit Aabom; Elisabeth Bendstrup; Per Sjøgren; Anders Løkke; Burhan Shaker; Torgny Wilcke; Bodil Abild Jespersen; Ole Hilberg; Kristoffer Marsaa

Opioider mod refraktær dyspnø i palliativ fase

Translated title of the contribution: Opioids for refractory dyspnoea in palliation

Birgit Aabom, Elisabeth Bendstrup, Per Sjøgren, Anders Løkke, Burhan Shaker, Torgny Wilcke, Bodil Abild Jespersen, Ole Hilberg, Kristoffer Marsaa

Abstract

Dyspnoea is cardinal symptom in chronic obstructive lung disease and common in palliative phases of cancer and other chronic medical diseases. Low-dose opioids is frequently used off-label. This review examines the evidence and safety as well as administration forms and pharmacokinetics using low dose opioids for dyspnoea. Conclusively, there seems to be clinical efficacy although further studies are needed. Furthermore, the authors recommend Danish Medical Agency to legislate low-dose morphine to palliative patients with refractory dyspnoea.

Translated title of the contribution	Opioids for refractory dyspnoea in palliation
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	182
Issue number	40
ISSN	0041-5782
Publication status	Published - 28 Sept 2020

Cite this

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title = "Opioider mod refrakt{\ae}r dyspn{\o} i palliativ fase",

abstract = "Dyspnoea is cardinal symptom in chronic obstructive lung disease and common in palliative phases of cancer and other chronic medical diseases. Low-dose opioids is frequently used off-label. This review examines the evidence and safety as well as administration forms and pharmacokinetics using low dose opioids for dyspnoea. Conclusively, there seems to be clinical efficacy although further studies are needed. Furthermore, the authors recommend Danish Medical Agency to legislate low-dose morphine to palliative patients with refractory dyspnoea.",

keywords = "Analgesics, Opioid/therapeutic use, Dyspnea/drug therapy, Humans, Morphine/therapeutic use, Palliative Care, Pulmonary Disease, Chronic Obstructive/complications",

author = "Birgit Aabom and Elisabeth Bendstrup and Per Sj{\o}gren and Anders L{\o}kke and Burhan Shaker and Torgny Wilcke and Jespersen, \{Bodil Abild\} and Ole Hilberg and Kristoffer Marsaa",

year = "2020",

month = sep,

day = "28",

language = "Dansk",

volume = "182",

journal = "Ugeskrift for Laeger",

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publisher = "Almindelige Danske Laegeforening",

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TY - JOUR

T1 - Opioider mod refraktær dyspnø i palliativ fase

AU - Aabom, Birgit

AU - Bendstrup, Elisabeth

AU - Sjøgren, Per

AU - Løkke, Anders

AU - Shaker, Burhan

AU - Wilcke, Torgny

AU - Jespersen, Bodil Abild

AU - Hilberg, Ole

AU - Marsaa, Kristoffer

PY - 2020/9/28

Y1 - 2020/9/28

N2 - Dyspnoea is cardinal symptom in chronic obstructive lung disease and common in palliative phases of cancer and other chronic medical diseases. Low-dose opioids is frequently used off-label. This review examines the evidence and safety as well as administration forms and pharmacokinetics using low dose opioids for dyspnoea. Conclusively, there seems to be clinical efficacy although further studies are needed. Furthermore, the authors recommend Danish Medical Agency to legislate low-dose morphine to palliative patients with refractory dyspnoea.

AB - Dyspnoea is cardinal symptom in chronic obstructive lung disease and common in palliative phases of cancer and other chronic medical diseases. Low-dose opioids is frequently used off-label. This review examines the evidence and safety as well as administration forms and pharmacokinetics using low dose opioids for dyspnoea. Conclusively, there seems to be clinical efficacy although further studies are needed. Furthermore, the authors recommend Danish Medical Agency to legislate low-dose morphine to palliative patients with refractory dyspnoea.

KW - Analgesics, Opioid/therapeutic use

KW - Dyspnea/drug therapy

KW - Humans

KW - Morphine/therapeutic use

KW - Palliative Care

KW - Pulmonary Disease, Chronic Obstructive/complications

UR - https://www.scopus.com/pages/publications/85092451175

M3 - Review

C2 - 33000737

SN - 0041-5782

VL - 182

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 40

ER -

Opioider mod refraktær dyspnø i palliativ fase

Abstract

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