On the etiology of incident brain lacunes: longitudinal observations from the LADIS study

Alida A Gouw; Wiesje M van der Flier; Leonardo Pantoni; Domenico Inzitari; Timo Erkinjuntti; Lars O Wahlund; Gunhild Waldemar; Reinhold Schmidt; Franz Fazekas; Philip Scheltens; Frederik Barkhof; LADIS study group; Olaf Bjarne Paulson

doi:10.1161/STROKEAHA.108.521807

On the etiology of incident brain lacunes: longitudinal observations from the LADIS study

Alida A Gouw, Wiesje M van der Flier, Leonardo Pantoni, Domenico Inzitari, Timo Erkinjuntti, Lars O Wahlund, Gunhild Waldemar, Reinhold Schmidt, Franz Fazekas, Philip Scheltens, Frederik Barkhof, LADIS study group, Olaf Bjarne Paulson (Member of author group)

Department of Neurology

80 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period.

METHODS: Baseline and 3-year follow-up MRI were collected within the LADIS study (n=358). Incident lacunes were characterized with respect to brain region, their appearance within pre-existent white matter hyperintensities (WMH), surrounding WMH size, and risk factors.

RESULTS: 106 incident lacunes were observed in 62 patients (58 subcortical white matter [WM], 35 basal ganglia, and 13 infratentorial). Incident subcortical WM lacunes occurred more often within preexisting WMH (P=0.01) and were mostly accompanied by new and expanded WMH (P<0.001), compared to incident basal ganglia and infratentorial lacunes. Risk factors for incident subcortical WM lacunes were history of hypertension and stroke, whereas atrial fibrillation predicted incident basal ganglia/infratentorial lacunes.

CONCLUSIONS: Differences in relation to WMH and risk factor profiles may suggest that incident lacunes in the subcortical WM have a different pathogenesis than those in the basal ganglia and infratentorial region.

Original language	English
Journal	Stroke
Volume	39
Issue number	11
Pages (from-to)	3083-5
Number of pages	3
ISSN	0039-2499
DOIs	https://doi.org/10.1161/STROKEAHA.108.521807
Publication status	Published - Nov 2008

Keywords

Basal Ganglia/pathology
Brain Infarction/etiology
Humans
Leukoaraiosis/pathology
Longitudinal Studies
Magnetic Resonance Imaging
Nerve Fibers, Myelinated/pathology
Risk Factors

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10.1161/STROKEAHA.108.521807

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title = "On the etiology of incident brain lacunes: longitudinal observations from the LADIS study",

abstract = "BACKGROUND AND PURPOSE: We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period.METHODS: Baseline and 3-year follow-up MRI were collected within the LADIS study (n=358). Incident lacunes were characterized with respect to brain region, their appearance within pre-existent white matter hyperintensities (WMH), surrounding WMH size, and risk factors.RESULTS: 106 incident lacunes were observed in 62 patients (58 subcortical white matter [WM], 35 basal ganglia, and 13 infratentorial). Incident subcortical WM lacunes occurred more often within preexisting WMH (P=0.01) and were mostly accompanied by new and expanded WMH (P<0.001), compared to incident basal ganglia and infratentorial lacunes. Risk factors for incident subcortical WM lacunes were history of hypertension and stroke, whereas atrial fibrillation predicted incident basal ganglia/infratentorial lacunes.CONCLUSIONS: Differences in relation to WMH and risk factor profiles may suggest that incident lacunes in the subcortical WM have a different pathogenesis than those in the basal ganglia and infratentorial region.",

keywords = "Basal Ganglia/pathology, Brain Infarction/etiology, Humans, Leukoaraiosis/pathology, Longitudinal Studies, Magnetic Resonance Imaging, Nerve Fibers, Myelinated/pathology, Risk Factors",

author = "Gouw, \{Alida A\} and \{van der Flier\}, \{Wiesje M\} and Leonardo Pantoni and Domenico Inzitari and Timo Erkinjuntti and Wahlund, \{Lars O\} and Gunhild Waldemar and Reinhold Schmidt and Franz Fazekas and Philip Scheltens and Frederik Barkhof and \{LADIS study group\} and Paulson, \{Olaf Bjarne\}",

year = "2008",

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doi = "10.1161/STROKEAHA.108.521807",

language = "English",

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T1 - On the etiology of incident brain lacunes

T2 - longitudinal observations from the LADIS study

AU - Gouw, Alida A

AU - van der Flier, Wiesje M

AU - Pantoni, Leonardo

AU - Inzitari, Domenico

AU - Erkinjuntti, Timo

AU - Wahlund, Lars O

AU - Waldemar, Gunhild

AU - Schmidt, Reinhold

AU - Fazekas, Franz

AU - Scheltens, Philip

AU - Barkhof, Frederik

AU - LADIS study group

A2 - Paulson, Olaf Bjarne

PY - 2008/11

Y1 - 2008/11

N2 - BACKGROUND AND PURPOSE: We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period.METHODS: Baseline and 3-year follow-up MRI were collected within the LADIS study (n=358). Incident lacunes were characterized with respect to brain region, their appearance within pre-existent white matter hyperintensities (WMH), surrounding WMH size, and risk factors.RESULTS: 106 incident lacunes were observed in 62 patients (58 subcortical white matter [WM], 35 basal ganglia, and 13 infratentorial). Incident subcortical WM lacunes occurred more often within preexisting WMH (P=0.01) and were mostly accompanied by new and expanded WMH (P<0.001), compared to incident basal ganglia and infratentorial lacunes. Risk factors for incident subcortical WM lacunes were history of hypertension and stroke, whereas atrial fibrillation predicted incident basal ganglia/infratentorial lacunes.CONCLUSIONS: Differences in relation to WMH and risk factor profiles may suggest that incident lacunes in the subcortical WM have a different pathogenesis than those in the basal ganglia and infratentorial region.

AB - BACKGROUND AND PURPOSE: We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period.METHODS: Baseline and 3-year follow-up MRI were collected within the LADIS study (n=358). Incident lacunes were characterized with respect to brain region, their appearance within pre-existent white matter hyperintensities (WMH), surrounding WMH size, and risk factors.RESULTS: 106 incident lacunes were observed in 62 patients (58 subcortical white matter [WM], 35 basal ganglia, and 13 infratentorial). Incident subcortical WM lacunes occurred more often within preexisting WMH (P=0.01) and were mostly accompanied by new and expanded WMH (P<0.001), compared to incident basal ganglia and infratentorial lacunes. Risk factors for incident subcortical WM lacunes were history of hypertension and stroke, whereas atrial fibrillation predicted incident basal ganglia/infratentorial lacunes.CONCLUSIONS: Differences in relation to WMH and risk factor profiles may suggest that incident lacunes in the subcortical WM have a different pathogenesis than those in the basal ganglia and infratentorial region.

KW - Basal Ganglia/pathology

KW - Brain Infarction/etiology

KW - Humans

KW - Leukoaraiosis/pathology

KW - Longitudinal Studies

KW - Magnetic Resonance Imaging

KW - Nerve Fibers, Myelinated/pathology

KW - Risk Factors

UR - https://www.scopus.com/pages/publications/55749087836

U2 - 10.1161/STROKEAHA.108.521807

DO - 10.1161/STROKEAHA.108.521807

M3 - Journal article

C2 - 18703801

SN - 0039-2499

VL - 39

SP - 3083

EP - 3085

JO - Stroke

JF - Stroke

IS - 11

ER -

On the etiology of incident brain lacunes: longitudinal observations from the LADIS study

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