Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Off-Label Prescription of Psychopharmacological Drugs in Child and Adolescent Psychiatry

Research output: Contribution to journalJournal articleResearchpeer-review

  1. How to Estimate QT Interval in Patients With Left or Right Bundle Branch Block: A Systematic Review

    Research output: Contribution to journalReviewResearchpeer-review

  2. Severe Parkinsonism and Creatine Kinase Increase After Low-Dose Aripiprazole Treatment in a Patient of African Descent

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Neurological, Metabolic, and Psychiatric Adverse Events in Children and Adolescents Treated With Aripiprazole

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Norquetiapine and Depressive Symptoms in Initially Antipsychotic-Naive First-Episode Schizophrenia

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. An observational study of emotion regulation in children with Tourette syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Søvnforstyrrelser hos børn og unge

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Selvmordsforebyggende klinikker for børn og unge med fokus på Region Hovedstaden

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

This study aimed to describe the frequency of off-label prescriptions of psychopharmacological drugs in a child and adolescent psychiatric setting. A cross-sectional study was conducted on November 1, 2014, including all inpatients and outpatients at the Mental Health Centre for Child and Adolescent Psychiatry, Capital Region of Denmark, aged 0 to 17 years receiving medical treatment with antidepressants, antipsychotic agents, benzodiazepines, melatonin and/or attention deficit hyperactivity disorder (ADHD) medication. We included a total of 5555 prescriptions representing 2932 patients. The main findings were that 32.3% of all prescriptions were off-label, and 41.6% of subjects received at least 1 off-label prescription. The most frequent off-label category was low age, 72.2%, meaning that the drug was not approved for the age group of the patient. The off-label rates for each drug class were as follows: melatonin, 100%; antipsychotic agents, 95.6%; benzodiazepines, 72.5%; antidepressants, 51.1%; and ADHD medication, 2.7%. Prescription of 2 or more psychopharmacological drugs per patient was common (31.5%). The group of subjects with 4 or more prescriptions (n = 36) was characterized by a higher frequency of inpatients, older age, and a different distribution of diagnoses. This study found a frequent use of off-label prescriptions when treating children and adolescents with psychopharmacological drugs other than ADHD medication. In addition, prescription of more than 1 psychotropic drug is common. These findings support the need for extending the evidence base for psychopharmacologic treatment in children and adolescents.

Original languageEnglish
JournalJournal of Clinical Psychopharmacology
Volume36
Issue number5
Pages (from-to)500-7
Number of pages7
ISSN0271-0749
DOIs
Publication statusPublished - Oct 2016

ID: 48367566