Ocular changes in a case of Kyrle's disease. 20-year follow-up

G A Alyahya; S Heegaard; J U Prause

doi:10.1034/j.1600-0420.2000.078005585.x

Ocular changes in a case of Kyrle's disease. 20-year follow-up

G A Alyahya, S Heegaard, J U Prause

12 Citations (Scopus)

Abstract

PURPOSE: To re-evaluate a case of Kyrle's disease with conjunctival and corneal changes in a 52-year-old patient with onset at the age of 5 years.

METHODS: Repeated biopsies from the skin, conjunctiva and oral mucosa along with a corneal button obtained from a right eye keratoplasty were examined histopathologically.

RESULTS: The skin, oral, conjunctival and corneal histopathology showed parakeratosis, dyskeratotic cells and single cell keratinization. The clinical picture and the histopathological findings are consistent with the diagnosis of Kyrle's disease.

CONCLUSIONS: This is the first reported case of Kyrle's disease with conjunctival changes. We suggest that Kyrle's disease, although predominantly affecting young adults, may also be seen in childhood. The disease may be a genodermatosis. It is not confined only to the skin, but can be seen in mucous membranes like the conjunctiva and buccal mucosa, and in tissues having the same embryological origin as the skin, i.e. the cornea.

Original language	English
Journal	Acta Ophthalmologica Scandinavica
Volume	78
Issue number	5
Pages (from-to)	585-9
Number of pages	5
ISSN	1395-3907
DOIs	https://doi.org/10.1034/j.1600-0420.2000.078005585.x
Publication status	Published - Oct 2000
Externally published	Yes

Keywords

Age of Onset
Conjunctiva/pathology
Conjunctival Diseases/diagnosis
Cornea/pathology
Corneal Diseases/diagnosis
Darier Disease/diagnosis
Diagnosis, Differential
Follow-Up Studies
Humans
Keratoplasty, Penetrating
Male
Middle Aged
Mouth Mucosa/pathology
Skin/pathology

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10.1034/j.1600-0420.2000.078005585.x

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title = "Ocular changes in a case of Kyrle's disease. 20-year follow-up",

abstract = "PURPOSE: To re-evaluate a case of Kyrle's disease with conjunctival and corneal changes in a 52-year-old patient with onset at the age of 5 years.METHODS: Repeated biopsies from the skin, conjunctiva and oral mucosa along with a corneal button obtained from a right eye keratoplasty were examined histopathologically.RESULTS: The skin, oral, conjunctival and corneal histopathology showed parakeratosis, dyskeratotic cells and single cell keratinization. The clinical picture and the histopathological findings are consistent with the diagnosis of Kyrle's disease.CONCLUSIONS: This is the first reported case of Kyrle's disease with conjunctival changes. We suggest that Kyrle's disease, although predominantly affecting young adults, may also be seen in childhood. The disease may be a genodermatosis. It is not confined only to the skin, but can be seen in mucous membranes like the conjunctiva and buccal mucosa, and in tissues having the same embryological origin as the skin, i.e. the cornea.",

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author = "Alyahya, \{G A\} and S Heegaard and Prause, \{J U\}",

year = "2000",

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doi = "10.1034/j.1600-0420.2000.078005585.x",

language = "English",

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T1 - Ocular changes in a case of Kyrle's disease. 20-year follow-up

AU - Alyahya, G A

AU - Heegaard, S

AU - Prause, J U

PY - 2000/10

Y1 - 2000/10

N2 - PURPOSE: To re-evaluate a case of Kyrle's disease with conjunctival and corneal changes in a 52-year-old patient with onset at the age of 5 years.METHODS: Repeated biopsies from the skin, conjunctiva and oral mucosa along with a corneal button obtained from a right eye keratoplasty were examined histopathologically.RESULTS: The skin, oral, conjunctival and corneal histopathology showed parakeratosis, dyskeratotic cells and single cell keratinization. The clinical picture and the histopathological findings are consistent with the diagnosis of Kyrle's disease.CONCLUSIONS: This is the first reported case of Kyrle's disease with conjunctival changes. We suggest that Kyrle's disease, although predominantly affecting young adults, may also be seen in childhood. The disease may be a genodermatosis. It is not confined only to the skin, but can be seen in mucous membranes like the conjunctiva and buccal mucosa, and in tissues having the same embryological origin as the skin, i.e. the cornea.

AB - PURPOSE: To re-evaluate a case of Kyrle's disease with conjunctival and corneal changes in a 52-year-old patient with onset at the age of 5 years.METHODS: Repeated biopsies from the skin, conjunctiva and oral mucosa along with a corneal button obtained from a right eye keratoplasty were examined histopathologically.RESULTS: The skin, oral, conjunctival and corneal histopathology showed parakeratosis, dyskeratotic cells and single cell keratinization. The clinical picture and the histopathological findings are consistent with the diagnosis of Kyrle's disease.CONCLUSIONS: This is the first reported case of Kyrle's disease with conjunctival changes. We suggest that Kyrle's disease, although predominantly affecting young adults, may also be seen in childhood. The disease may be a genodermatosis. It is not confined only to the skin, but can be seen in mucous membranes like the conjunctiva and buccal mucosa, and in tissues having the same embryological origin as the skin, i.e. the cornea.

KW - Age of Onset

KW - Conjunctiva/pathology

KW - Conjunctival Diseases/diagnosis

KW - Cornea/pathology

KW - Corneal Diseases/diagnosis

KW - Darier Disease/diagnosis

KW - Diagnosis, Differential

KW - Follow-Up Studies

KW - Humans

KW - Keratoplasty, Penetrating

KW - Male

KW - Middle Aged

KW - Mouth Mucosa/pathology

KW - Skin/pathology

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DO - 10.1034/j.1600-0420.2000.078005585.x

M3 - Journal article

C2 - 11037920

SN - 1395-3907

VL - 78

SP - 585

EP - 589

JO - Acta Ophthalmologica Scandinavica

JF - Acta Ophthalmologica Scandinavica

IS - 5

ER -

Ocular changes in a case of Kyrle's disease. 20-year follow-up

Abstract

Keywords

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