Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Occupational exposures and exacerbations of asthma and COPD-A general population study

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{8a991688b9ad424bbf5f0dc9c306a492,
title = "Occupational exposures and exacerbations of asthma and COPD-A general population study",
abstract = "PURPOSE: Recent studies suggest that occupational inhalant exposures trigger exacerbations of asthma and chronic obstructive pulmonary disease, but findings are conflicting.METHODS: We included 7,768 individuals with self-reported asthma (n = 3,215) and/or spirometric airflow limitation (forced expiratory volume in 1 second (FEV1)/ forced expiratory volume (FVC) <0.70) (n = 5,275) who participated in The Copenhagen City Heart Study or The Copenhagen General Population Study from 2001-2016. Occupational exposure was assigned by linking job codes with job exposure matrices, and exacerbations were defined by register data on oral corticosteroid treatment, emergency care unit assessment or hospital admission. Associations between occupational inhalant exposure each year of follow-up and exacerbation were assessed by Cox regression with time varying exposure and age as the underlying time scale.RESULTS: Participants were followed for a median of 4.6 years (interquartile range, IQR 5.4), during which 870 exacerbations occurred. Exacerbations were not associated with any of the selected exposures (high molecular weight sensitizers, low molecular weight sensitizers, irritants or low and high levels of mineral dust, biological dust, gases & fumes or the composite variable vapours, gases, dusts or fumes). Hazards ratios ranged from 0.8 (95% confidence interval: 0.7;1.0) to 1.2 (95% confidence interval: 0.9;1.7).CONCLUSION: Exacerbations of obstructive airway disease were not associated with occupational inhalant exposures assigned by a job exposure matrix. Further studies with alternative exposure assessment are warranted.",
author = "Stinna Skaaby and Flachs, {Esben Meulengracht} and Peter Lange and Vivi Schl{\"u}nssen and Marott, {Jacob Louis} and Charlotte Brauer and Nordestgaard, {B{\o}rge G} and Steven Sadhra and Om Kurmi and Bonde, {Jens Peter Ellekilde}",
year = "2020",
month = dec,
doi = "10.1371/journal.pone.0243826",
language = "English",
volume = "15",
pages = "e0243826",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "12 December",

}

RIS

TY - JOUR

T1 - Occupational exposures and exacerbations of asthma and COPD-A general population study

AU - Skaaby, Stinna

AU - Flachs, Esben Meulengracht

AU - Lange, Peter

AU - Schlünssen, Vivi

AU - Marott, Jacob Louis

AU - Brauer, Charlotte

AU - Nordestgaard, Børge G

AU - Sadhra, Steven

AU - Kurmi, Om

AU - Bonde, Jens Peter Ellekilde

PY - 2020/12

Y1 - 2020/12

N2 - PURPOSE: Recent studies suggest that occupational inhalant exposures trigger exacerbations of asthma and chronic obstructive pulmonary disease, but findings are conflicting.METHODS: We included 7,768 individuals with self-reported asthma (n = 3,215) and/or spirometric airflow limitation (forced expiratory volume in 1 second (FEV1)/ forced expiratory volume (FVC) <0.70) (n = 5,275) who participated in The Copenhagen City Heart Study or The Copenhagen General Population Study from 2001-2016. Occupational exposure was assigned by linking job codes with job exposure matrices, and exacerbations were defined by register data on oral corticosteroid treatment, emergency care unit assessment or hospital admission. Associations between occupational inhalant exposure each year of follow-up and exacerbation were assessed by Cox regression with time varying exposure and age as the underlying time scale.RESULTS: Participants were followed for a median of 4.6 years (interquartile range, IQR 5.4), during which 870 exacerbations occurred. Exacerbations were not associated with any of the selected exposures (high molecular weight sensitizers, low molecular weight sensitizers, irritants or low and high levels of mineral dust, biological dust, gases & fumes or the composite variable vapours, gases, dusts or fumes). Hazards ratios ranged from 0.8 (95% confidence interval: 0.7;1.0) to 1.2 (95% confidence interval: 0.9;1.7).CONCLUSION: Exacerbations of obstructive airway disease were not associated with occupational inhalant exposures assigned by a job exposure matrix. Further studies with alternative exposure assessment are warranted.

AB - PURPOSE: Recent studies suggest that occupational inhalant exposures trigger exacerbations of asthma and chronic obstructive pulmonary disease, but findings are conflicting.METHODS: We included 7,768 individuals with self-reported asthma (n = 3,215) and/or spirometric airflow limitation (forced expiratory volume in 1 second (FEV1)/ forced expiratory volume (FVC) <0.70) (n = 5,275) who participated in The Copenhagen City Heart Study or The Copenhagen General Population Study from 2001-2016. Occupational exposure was assigned by linking job codes with job exposure matrices, and exacerbations were defined by register data on oral corticosteroid treatment, emergency care unit assessment or hospital admission. Associations between occupational inhalant exposure each year of follow-up and exacerbation were assessed by Cox regression with time varying exposure and age as the underlying time scale.RESULTS: Participants were followed for a median of 4.6 years (interquartile range, IQR 5.4), during which 870 exacerbations occurred. Exacerbations were not associated with any of the selected exposures (high molecular weight sensitizers, low molecular weight sensitizers, irritants or low and high levels of mineral dust, biological dust, gases & fumes or the composite variable vapours, gases, dusts or fumes). Hazards ratios ranged from 0.8 (95% confidence interval: 0.7;1.0) to 1.2 (95% confidence interval: 0.9;1.7).CONCLUSION: Exacerbations of obstructive airway disease were not associated with occupational inhalant exposures assigned by a job exposure matrix. Further studies with alternative exposure assessment are warranted.

UR - http://www.scopus.com/inward/record.url?scp=85099115962&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0243826

DO - 10.1371/journal.pone.0243826

M3 - Journal article

C2 - 33370308

VL - 15

SP - e0243826

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 12 December

M1 - e0243826

ER -

ID: 61899070