Nye hormoner relateret til calcium- og fosfathomøostasen ved nyresygdom

Maria Lerche Mace; Klaus Ølgaard; Eva Lewin

Nye hormoner relateret til calcium- og fosfathomøostasen ved nyresygdom

Translated title of the contribution: Novel hormones related to the calcium and phosphate homeostasis in kidney disease

Maria Lerche Mace, Klaus Ølgaard, Eva Lewin

Department of Nephrology

Abstract

Calcium and phosphate levels are regulated by a complex interplay between parathyroid hormone (PTH), calcitriol, fibroblast growth factor 23 (FGF23) and its co-receptor αKlotho. Kidney failure causes severe disturbances in the mineral and bone homeostasis resulting in phosphate retention, hypocalcaemia and high plasma levels of FGF23 and PTH, and the patients develop fragile bones and vascular calcifications. Today's treatments aim to lower the levels of phosphate and PTH. Future studies need to clarify, if lowering the FGF23 level or supplementation with αKlotho will improve survival for patients with chronic kidney disease.

Translated title of the contribution	Novel hormones related to the calcium and phosphate homeostasis in kidney disease
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	180
Issue number	21
Pages (from-to)	V05170353
ISSN	0041-5782
Publication status	Published - 21 May 2018

Cite this

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title = "Nye hormoner relateret til calcium- og fosfathom{\o}ostasen ved nyresygdom",

abstract = "Calcium and phosphate levels are regulated by a complex interplay between parathyroid hormone (PTH), calcitriol, fibroblast growth factor 23 (FGF23) and its co-receptor αKlotho. Kidney failure causes severe disturbances in the mineral and bone homeostasis resulting in phosphate retention, hypocalcaemia and high plasma levels of FGF23 and PTH, and the patients develop fragile bones and vascular calcifications. Today's treatments aim to lower the levels of phosphate and PTH. Future studies need to clarify, if lowering the FGF23 level or supplementation with αKlotho will improve survival for patients with chronic kidney disease.",

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AU - Mace, Maria Lerche

AU - Ølgaard, Klaus

AU - Lewin, Eva

PY - 2018/5/21

Y1 - 2018/5/21

N2 - Calcium and phosphate levels are regulated by a complex interplay between parathyroid hormone (PTH), calcitriol, fibroblast growth factor 23 (FGF23) and its co-receptor αKlotho. Kidney failure causes severe disturbances in the mineral and bone homeostasis resulting in phosphate retention, hypocalcaemia and high plasma levels of FGF23 and PTH, and the patients develop fragile bones and vascular calcifications. Today's treatments aim to lower the levels of phosphate and PTH. Future studies need to clarify, if lowering the FGF23 level or supplementation with αKlotho will improve survival for patients with chronic kidney disease.

AB - Calcium and phosphate levels are regulated by a complex interplay between parathyroid hormone (PTH), calcitriol, fibroblast growth factor 23 (FGF23) and its co-receptor αKlotho. Kidney failure causes severe disturbances in the mineral and bone homeostasis resulting in phosphate retention, hypocalcaemia and high plasma levels of FGF23 and PTH, and the patients develop fragile bones and vascular calcifications. Today's treatments aim to lower the levels of phosphate and PTH. Future studies need to clarify, if lowering the FGF23 level or supplementation with αKlotho will improve survival for patients with chronic kidney disease.

UR - https://www.scopus.com/pages/publications/85065288805

M3 - Tidsskriftartikel

C2 - 29804564

SN - 0041-5782

VL - 180

SP - V05170353

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 21

ER -

Nye hormoner relateret til calcium- og fosfathomøostasen ved nyresygdom

Abstract

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