Ny test til diagnostik af tuberkulose

Translated title of the contribution: New diagnostic test for tuberculosis

Pernille Ravn, Michala Vaaben Rose, Bolette Søborg, Ase Bengård Andersen

2 Citations (Scopus)

Abstract

The performance of two commercially-available Interferon Gamma Release Assays, QuantiFERON-TB-Gold and T-SPOT-TB, is reviewed. The tests can indirectly detect M. tuberculosis infection based on T-cell recognition of specific proteins which are not present in the BCG vaccine M. avium, or most other environmental mycobacteria.The sensitivity (76-88%) of the IGRAs is not optimal for a diagnostic test for active tuberculosis. However, the specificity is high (92-97%), and the IGRAs may play an important role in the investigation for active tuberculosis and screening for latent tuberculosis infection in BCG vaccinated populations and immunosuppressed patients.
Udgivelsesdato: 2009-Sep-7
Translated title of the contributionNew diagnostic test for tuberculosis
Original languageDanish
JournalUgeskr Laeger
Volume171
Issue number37
Pages (from-to)2635-9
Number of pages4
Publication statusPublished - 2009

Keywords

  • Adult
  • Biological Markers
  • Child
  • Contact Tracing
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Immunocompromised Host
  • Interferon-gamma
  • Mycobacterium tuberculosis
  • Risk Factors
  • Sensitivity and Specificity
  • Tuberculin Test
  • Tuberculosis

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