TY - JOUR
T1 - Ny behandling af gliomer rettet mod specifikt mikro-RNA
AU - Halle, Bo
AU - Andersen, Claus
AU - Schulz, Mette Katrine
AU - Kristensen, Bjarne Winther
PY - 2012/3/5
Y1 - 2012/3/5
N2 - Recent research has revealed the existence of a class of small non-coding RNAs, known as microRNAs. These microRNAs are deregulated in various cancers including gliomas. MicroRNAs have been suggested to be important in cancer stem cell biology and in proliferation and chemosensitivity of cancer cells. This makes microRNAs obvious targets for novel therapeutic strategies. In the present article we focus on the role of microRNAs in cancer cells and cancer stem cells as well as the possible therapeutic approaches exploiting this knowledge to improve future glioma therapy.
AB - Recent research has revealed the existence of a class of small non-coding RNAs, known as microRNAs. These microRNAs are deregulated in various cancers including gliomas. MicroRNAs have been suggested to be important in cancer stem cell biology and in proliferation and chemosensitivity of cancer cells. This makes microRNAs obvious targets for novel therapeutic strategies. In the present article we focus on the role of microRNAs in cancer cells and cancer stem cells as well as the possible therapeutic approaches exploiting this knowledge to improve future glioma therapy.
KW - Antineoplastic Agents/administration & dosage
KW - Brain Neoplasms/drug therapy
KW - Convection
KW - Drug Delivery Systems/methods
KW - Gene Expression Regulation, Neoplastic/genetics
KW - Glioblastoma/drug therapy
KW - Glioma/drug therapy
KW - Humans
KW - MicroRNAs/drug effects
KW - Neoplastic Stem Cells/drug effects
M3 - Tidsskriftartikel
C2 - 22395010
SN - 0041-5782
VL - 174
SP - 630
EP - 633
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
IS - 10
ER -