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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Novel use of the ovarian follicular pool to postpone menopause and delay osteoporosis

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  1. Meditation and mindfulness reduce perceived stress in women with recurrent pregnancy loss: a randomized controlled trial

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  2. Stress and depression among women and men who have experienced recurrent pregnancy loss: focusing on both sexes

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  3. Empathetic application of machine learning may address appropriate utilization of ART

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  4. Futures and fears in the freezer: Danish women's experiences with ovarian tissue cryopreservation and transplantation

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  5. The reproductive microbiome - clinical practice recommendations for fertility specialists

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  1. Crown-rump length measurement error: impact on assessment of growth

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  2. Proteome of fluid from human ovarian small antral follicles reveals insights in folliculogenesis and oocyte maturation

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  3. N-acetylcysteine protects ovarian follicles from ischemia-reperfusion injury in xenotransplanted human ovarian tissue

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  4. Umbilical cord blood-derived platelet-rich plasma: a clinically acceptable substitute for fetal bovine serum?

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  5. Parental Acceptance Rate of Testicular Tissue Cryopreservation in Danish Boys with Cryptorchidism

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Life expectancy has increased by more than 30 years during the last century and continues to increase. Many women already live decades in menopause deprived of naturally produced oestradiol and progesterone, leading to an increasing incidence of menopause-related disorders such as osteoporosis, cardiovascular diseases and lack of general well-being. Exogenous oestradiol has traditionally been used to alleviate menopause-related effects. This commentary discusses a radical new method to postpone menopause. Part of the enormous surplus of ovarian follicles can now be cryostored in youth for use after menopause. Excision of ovarian tissue will advance menopause marginally and will not reduce natural fertility. Grafted tissue restores ovarian function with circulating concentrations of sex steroids for years in post-menopausal cancer survivors. Future developments may further utilize the enormous store of ovarian follicles. Currently, the main goal of ovarian cryopreservation is fertility preservation, but grafting of ovarian tissue may also serve endocrine functions as a physiological solution to prevent the massive medical legacy of osteoporosis and menopause-related conditions in the ageing population. This intriguing solution is now technically available; the question is whether this method qualifies for postponing menopause, perhaps initially for those patients who already have cryostored tissue?

Original languageEnglish
JournalReproductive BioMedicine Online
Volume31
Issue number2
Pages (from-to)128-31
Number of pages4
ISSN1472-6483
DOIs
Publication statusPublished - Aug 2015

ID: 46037694