Novel susceptibility locus at 22q11 for diabetic nephropathy in type 1 diabetes

Maija Wessman; Carol Forsblom; Mari A Kaunisto; Jenny Söderlund; Jorma Ilonen; Riitta Sallinen; Tero Hiekkalinna; Maija Parkkonen; Alexander P Maxwell; Lise Tarnow; Hans-Henrik Parving; Samy Hadjadj; Michel Marre; Leena Peltonen; Per-Henrik Groop; FinnDiane Study Group

doi:10.1371/journal.pone.0024053

Novel susceptibility locus at 22q11 for diabetic nephropathy in type 1 diabetes

Maija Wessman, Carol Forsblom, Mari A Kaunisto, Jenny Söderlund, Jorma Ilonen, Riitta Sallinen, Tero Hiekkalinna, Maija Parkkonen, Alexander P Maxwell, Lise Tarnow, Hans-Henrik Parving, Samy Hadjadj, Michel Marre, Leena Peltonen, Per-Henrik Groop, FinnDiane Study Group

13 Citations (Scopus)

Abstract

Diabetic nephropathy (DN) affects about 30% of patients with type 1 diabetes (T1D) and contributes to serious morbidity and mortality. So far only the 3q21-q25 region has repeatedly been indicated as a susceptibility region for DN. The aim of this study was to search for new DN susceptibility loci in Finnish, Danish and French T1D families.

Original language	English
Journal	P L o S One
Volume	6
Issue number	9
Pages (from-to)	e24053
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0024053
Publication status	Published - 2011

Keywords

Adult
Chromosome Mapping
Chromosomes, Human, Pair 22
Denmark
Diabetes Mellitus, Type 1
Diabetic Nephropathies
Family
Female
Finland
France
Genetic Linkage
Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study
HLA Antigens
Humans
Male
Siblings

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Wessman, M., Forsblom, C., Kaunisto, M. A., Söderlund, J., Ilonen, J., Sallinen, R., Hiekkalinna, T., Parkkonen, M., Maxwell, A. P., Tarnow, L., Parving, H.-H., Hadjadj, S., Marre, M., Peltonen, L., Groop, P.-H., & FinnDiane Study Group (2011). Novel susceptibility locus at 22q11 for diabetic nephropathy in type 1 diabetes. P L o S One, 6(9), e24053. https://doi.org/10.1371/journal.pone.0024053

Wessman, M, Forsblom, C, Kaunisto, MA, Söderlund, J, Ilonen, J, Sallinen, R, Hiekkalinna, T, Parkkonen, M, Maxwell, AP, Tarnow, L, Parving, H-H, Hadjadj, S, Marre, M, Peltonen, L, Groop, P-H & FinnDiane Study Group 2011, 'Novel susceptibility locus at 22q11 for diabetic nephropathy in type 1 diabetes', P L o S One, vol. 6, no. 9, pp. e24053. https://doi.org/10.1371/journal.pone.0024053

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abstract = "Diabetic nephropathy (DN) affects about 30\% of patients with type 1 diabetes (T1D) and contributes to serious morbidity and mortality. So far only the 3q21-q25 region has repeatedly been indicated as a susceptibility region for DN. The aim of this study was to search for new DN susceptibility loci in Finnish, Danish and French T1D families.",

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doi = "10.1371/journal.pone.0024053",

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T1 - Novel susceptibility locus at 22q11 for diabetic nephropathy in type 1 diabetes

AU - Wessman, Maija

AU - Forsblom, Carol

AU - Kaunisto, Mari A

AU - Söderlund, Jenny

AU - Ilonen, Jorma

AU - Sallinen, Riitta

AU - Hiekkalinna, Tero

AU - Parkkonen, Maija

AU - Maxwell, Alexander P

AU - Tarnow, Lise

AU - Parving, Hans-Henrik

AU - Hadjadj, Samy

AU - Marre, Michel

AU - Peltonen, Leena

AU - Groop, Per-Henrik

AU - FinnDiane Study Group

PY - 2011

Y1 - 2011

N2 - Diabetic nephropathy (DN) affects about 30% of patients with type 1 diabetes (T1D) and contributes to serious morbidity and mortality. So far only the 3q21-q25 region has repeatedly been indicated as a susceptibility region for DN. The aim of this study was to search for new DN susceptibility loci in Finnish, Danish and French T1D families.

AB - Diabetic nephropathy (DN) affects about 30% of patients with type 1 diabetes (T1D) and contributes to serious morbidity and mortality. So far only the 3q21-q25 region has repeatedly been indicated as a susceptibility region for DN. The aim of this study was to search for new DN susceptibility loci in Finnish, Danish and French T1D families.

KW - Adult

KW - Chromosome Mapping

KW - Chromosomes, Human, Pair 22

KW - Denmark

KW - Diabetes Mellitus, Type 1

KW - Diabetic Nephropathies

KW - Family

KW - Female

KW - Finland

KW - France

KW - Genetic Linkage

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - HLA Antigens

KW - Humans

KW - Male

KW - Siblings

UR - https://www.scopus.com/pages/publications/80052355230

U2 - 10.1371/journal.pone.0024053

DO - 10.1371/journal.pone.0024053

M3 - Journal article

C2 - 21909410

SN - 1932-6203

VL - 6

SP - e24053

JO - P L o S One

JF - P L o S One

IS - 9

ER -

Novel susceptibility locus at 22q11 for diabetic nephropathy in type 1 diabetes

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Keywords

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