Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension

Diana Julie Leeming; M A Karsdal; I Byrjalsen; C Christiansen; F Bendtsen; J Trebicka; M J Nielsen; Søren Møller; A Krag

doi:10.1111/apt.12484

Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension

Diana Julie Leeming, M A Karsdal, I Byrjalsen, C Christiansen, F Bendtsen, J Trebicka, M J Nielsen, Søren Møller, A Krag

100 Citations (Scopus)

Abstract

The hepatic venous pressure gradient (HVPG) is an invasive, but important diagnostic and prognostic marker in cirrhosis with portal hypertension (PHT). During cirrhosis, remodelling of fibrotic tissue by matrix metalloproteinases (MMPs) is a permanent process generating small fragments of degraded extracellular matrix (ECM) proteins known as neoepitopes, which are then released into the circulation.

Original language	English
Journal	Alimentary Pharmacology and Therapeutics
Volume	38
Issue number	9
Pages (from-to)	1086-96
Number of pages	11
ISSN	0269-2813
DOIs	https://doi.org/10.1111/apt.12484
Publication status	Published - Nov 2013

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10.1111/apt.12484

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title = "Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension",

abstract = "The hepatic venous pressure gradient (HVPG) is an invasive, but important diagnostic and prognostic marker in cirrhosis with portal hypertension (PHT). During cirrhosis, remodelling of fibrotic tissue by matrix metalloproteinases (MMPs) is a permanent process generating small fragments of degraded extracellular matrix (ECM) proteins known as neoepitopes, which are then released into the circulation.",

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AU - Leeming, Diana Julie

AU - Karsdal, M A

AU - Byrjalsen, I

AU - Christiansen, C

AU - Bendtsen, F

AU - Trebicka, J

AU - Nielsen, M J

AU - Møller, Søren

AU - Krag, A

PY - 2013/11

Y1 - 2013/11

N2 - The hepatic venous pressure gradient (HVPG) is an invasive, but important diagnostic and prognostic marker in cirrhosis with portal hypertension (PHT). During cirrhosis, remodelling of fibrotic tissue by matrix metalloproteinases (MMPs) is a permanent process generating small fragments of degraded extracellular matrix (ECM) proteins known as neoepitopes, which are then released into the circulation.

AB - The hepatic venous pressure gradient (HVPG) is an invasive, but important diagnostic and prognostic marker in cirrhosis with portal hypertension (PHT). During cirrhosis, remodelling of fibrotic tissue by matrix metalloproteinases (MMPs) is a permanent process generating small fragments of degraded extracellular matrix (ECM) proteins known as neoepitopes, which are then released into the circulation.

UR - https://www.scopus.com/pages/publications/84885088369

U2 - 10.1111/apt.12484

DO - 10.1111/apt.12484

M3 - Journal article

C2 - 24099470

SN - 0269-2813

VL - 38

SP - 1086

EP - 1096

JO - Alimentary Pharmacology and Therapeutics

JF - Alimentary Pharmacology and Therapeutics

IS - 9

ER -

Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension

Abstract

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