Novel insights into cerebral palsy

Else Marie Bartels, Lise Korbo, Adrian P Harrison

8 Citations (Scopus)

Abstract

Cerebral palsy (CP) is a neurodevelopmental disorder characterized by abnormalities of muscle tone, movement and motor skills, and is attributed to injury to the developing brain. CP affects about 1 in 500 neonates. CP shows clinical features which evolve with age, and these may over time lead to deterioration of motor function although the lesion to the developing brain is non-progressive. The underlying causes for CP remain unclear. Based on recent research we are able to give a physiological explanation on the appearance and development of the condition. The damage to the central nervous system causes a change in collagen structure, with a higher level of deposition of collagen around the muscles, increasing throughout life. Assuming this premise is correct, the question is, will it by any treatment be possible to delay or prevent this collagen accumulation in the CP muscles, thereby giving CP patients a better prognosis in the future.

Original languageEnglish
JournalJournal of muscle research and cell motility
Volume41
Issue number2-3
Pages (from-to)265-267
Number of pages3
ISSN0142-4319
DOIs
Publication statusPublished - Sept 2020

Keywords

  • Cerebral palsy
  • Collagen
  • Muscle

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