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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Novel Insights From Human Studies on the Role of High-Density Lipoprotein in Mortality and Noncardiovascular Disease

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  1. Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 promote the transendothelial transport of High-Density Lipoprotein

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  2. Low High-Density Lipoprotein Cholesterol and High White Blood Cell Counts: A Mendelian Randomization Study

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  3. Plasma Albumin and Incident Cardiovascular Disease: Results From the CGPS and an Updated Meta-Analysis

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  4. Smoking and Increased White and Red Blood Cells: A Mendelian Randomization Approach in the Copenhagen General Population Study

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    Research output: Contribution to journalLetterResearchpeer-review

  2. Occupational inhalant exposures and longitudinal lung function decline

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  3. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

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The vast majority of research about HDL (high-density lipoprotein) has for decades revolved around the possible role of HDL in atherosclerosis and its therapeutic potential within cardiovascular disease prevention; however, failures with therapies aimed at increasing HDL cholesterol has left questions as to what the role and function of HDL in human health and disease is. Recent observational studies have further shown that extreme high HDL cholesterol is associated with high mortality leading to speculations that HDL could in some instances be harmful. In addition, evidence from observational, and to a lesser extent genetic studies has emerged indicating that HDL might be associated with the development of other major noncardiovascular diseases, such as infectious disease, autoimmune disease, cancer, type 2 diabetes, kidney disease, and lung disease. In this review, we discuss (1) the association between extreme high HDL cholesterol and mortality and (2) the emerging human evidence linking HDL to several major diseases outside the realm of cardiovascular disease.

Original languageEnglish
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume41
Issue number1
Pages (from-to)128-140
Number of pages13
ISSN1079-5642
DOIs
Publication statusPublished - Jan 2021

    Research areas

  • Atherosclerosis, Cardiovascular diseases, Lipids, Lipoproteins, Mortality

ID: 61929749