Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Novel Anti-inflammatory Treatments in Cirrhosis. A Literature-Based Study

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. The apoM/S1P complex - a mediator in kidney biology and disease?

    Research output: Contribution to journalReviewResearchpeer-review

  2. Magnetic Resonance Imaging of Enthesitis in Spondyloarthritis, Including Psoriatic Arthritis-Status and Recent Advances

    Research output: Contribution to journalReviewResearchpeer-review

  3. Intradermal Tests With Drugs: An Approach to Standardization

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Progressive alcohol-related liver fibrosis is characterised by imbalanced collagen formation and degradation

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Using MR elastography to assess portal hypertension and response to beta-blockers in patients with cirrhosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: Overlapping Mechanisms

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

Liver cirrhosis is a disease characterised by multiple complications and a poor prognosis. The prevalence is increasing worldwide. Chronic inflammation is ongoing in liver cirrhosis. No cure for the inflammation is available, and the current treatment of liver cirrhosis is only symptomatic. However, several different medical agents have been suggested as potential healing drugs. The majority are tested in rodents, but few human trials are effectuated. This review focuses on medical agents described in the literature with supposed alleviating and curing effects on liver cirrhosis. Twelve anti-inflammatory, five antioxidative, and three drugs with effects on gut microflora and the LPS pathway were found. Two drugs not categorised by the three former categories were found in addition. In total, 42 rodent studies and seven human trials were found. Promising effects of celecoxib, aspirin, curcumin, kahweol, pentoxifylline, diosmin, statins, emricasan, and silymarin were found in cirrhotic rodent models. Few indices of effects of etanercept, glycyrrhizin arginine salt, and mitoquinone were found. Faecal microbiota transplantation is in increasing searchlight with a supposed potential to alleviate cirrhosis. However, human trials are in demand to verify the findings in this review.

Original languageEnglish
Article number718896
JournalFrontiers in Medicine
Volume8
ISSN2296-858X
DOIs
Publication statusPublished - 23 Sep 2021

Bibliographical note

Copyright © 2021 Kronborg, Ytting, Hobolth, Møller and Kimer.

    Research areas

  • anti-oxidation, cirrhosis models, cytokines, inflammation, liver cirrhosis, treatment

ID: 68352526