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Notch Signaling and Brain Tumors

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Human brain tumors are a heterogenous group of neoplasms occurring inside the cranium and the central spinal cord. In adults and children, astrocytic glioma and medulloblastoma are the most common subtypes of primary brain tumors. These tumor types are thought to arise from cells in which Notch signaling plays a fundamental role during development. Recent findings have shown that Notch signaling is dysregulated, and contributes to the malignant potential of these tumors. Growing evidence point towards an important role for cancer stem cells in the initiation and maintenance of glioma and medulloblastoma. In this chapter we will cover the present findings of Notch signaling in human glioma and medulloblastoma and try to create an overall picture of its relevance in the pathogenesis of these tumors.
Original languageEnglish
Title of host publicationNotch signaling in embryology and cancer
EditorsJörg Reichrath, Sandra Reichrath
Number of pages16
Volume727
PublisherLandes Bioscience
Publication date22 Dec 2011
Pages289-304
Chapter22
ISBN (Print)978-1-4614-0898-7
Publication statusPublished - 22 Dec 2011

ID: 32225707