TY - JOUR
T1 - Normovolemia defined according to cardiac stroke volume in healthy supine humans
AU - Bundgaard-Nielsen, Morten
AU - Jørgensen, Christoffer C
AU - Kehlet, Henrik
AU - Secher, Niels H
PY - 2010/9/1
Y1 - 2010/9/1
N2 - Both hypovolemia and a fluid overload are detrimental for outcome in surgical patients but the effort to establish normovolemia is hampered by the lack of an operational clinical definition. Manipulating the central blood volume on a tilt table demonstrates that the flat part of the Frank-Starling curve is reached when subjects are supine and that finding may be applicable for a clinical definition of normovolemia. However, it is unknown whether stroke volume (SV) responds to an increase in preload induced by fluid administration.
AB - Both hypovolemia and a fluid overload are detrimental for outcome in surgical patients but the effort to establish normovolemia is hampered by the lack of an operational clinical definition. Manipulating the central blood volume on a tilt table demonstrates that the flat part of the Frank-Starling curve is reached when subjects are supine and that finding may be applicable for a clinical definition of normovolemia. However, it is unknown whether stroke volume (SV) responds to an increase in preload induced by fluid administration.
U2 - 10.1111/j.1475-097X.2010.00944.x
DO - 10.1111/j.1475-097X.2010.00944.x
M3 - Journal article
C2 - 20545713
SN - 1475-0961
VL - 30
SP - 318
EP - 322
JO - Clinical Physiology and Functional Imaging
JF - Clinical Physiology and Functional Imaging
IS - 5
ER -