TY - JOUR
T1 - Normal T and B Cell Responses Against SARS-CoV-2 in a Family With a Non-Functional Vitamin D Receptor
T2 - A Case Report
AU - Kongsbak-Wismann, Martin
AU - Al-Jaberi, Fatima A H
AU - Schmidt, Jonas Damgård
AU - Ghanizada, Mustafa
AU - Hansen, Cecilie Bo
AU - Lopez, Daniel Villalba
AU - Woetmann, Anders
AU - Ødum, Niels
AU - Bonefeld, Charlotte Menné
AU - Stryhn, Anette
AU - Garred, Peter
AU - Buus, Søren
AU - Geisler, Carsten
N1 - Copyright © 2021 Kongsbak-Wismann, Al-Jaberi, Schmidt, Ghanizada, Hansen, Lopez, Woetmann, Ødum, Bonefeld, Stryhn, Garred, Buus and Geisler.
PY - 2021
Y1 - 2021
N2 - The coronavirus disease 2019 (COVID-19) pandemic has severely impacted daily life all over the world. Any measures to slow down the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to decrease disease severity are highly requested. Recent studies have reported inverse correlations between plasma levels of vitamin D and susceptibility to SARS-CoV-2 infection and COVID-19 severity. Therefore, it has been proposed to supplement the general population with vitamin D to reduce the impact of COVID-19. However, by studying the course of COVID-19 and the immune response against SARS-CoV-2 in a family with a mutated, non-functional vitamin D receptor, we here demonstrate that vitamin D signaling was dispensable for mounting an efficient adaptive immune response against SARS-CoV-2 in this family. Although these observations might not directly be transferred to the general population, they question a central role of vitamin D in the generation of adaptive immunity against SARS-CoV-2.
AB - The coronavirus disease 2019 (COVID-19) pandemic has severely impacted daily life all over the world. Any measures to slow down the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to decrease disease severity are highly requested. Recent studies have reported inverse correlations between plasma levels of vitamin D and susceptibility to SARS-CoV-2 infection and COVID-19 severity. Therefore, it has been proposed to supplement the general population with vitamin D to reduce the impact of COVID-19. However, by studying the course of COVID-19 and the immune response against SARS-CoV-2 in a family with a mutated, non-functional vitamin D receptor, we here demonstrate that vitamin D signaling was dispensable for mounting an efficient adaptive immune response against SARS-CoV-2 in this family. Although these observations might not directly be transferred to the general population, they question a central role of vitamin D in the generation of adaptive immunity against SARS-CoV-2.
KW - Adaptive Immunity/genetics
KW - B-Lymphocytes/immunology
KW - CD4-Positive T-Lymphocytes/immunology
KW - CD8-Positive T-Lymphocytes/immunology
KW - COVID-19/immunology
KW - Familial Hypophosphatemic Rickets/genetics
KW - Female
KW - Humans
KW - Immunologic Memory/immunology
KW - Lymphocyte Count
KW - Receptors, Calcitriol/genetics
KW - SARS-CoV-2/immunology
KW - Vitamin D/blood
UR - http://www.scopus.com/inward/record.url?scp=85117089963&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2021.758154
DO - 10.3389/fimmu.2021.758154
M3 - Journal article
C2 - 34659264
SN - 1664-3224
VL - 12
SP - 758154
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 758154
ER -