Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Non-invasive methods for measuring vascular changes in neurovascular headaches

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. Cigarette smoking and cerebral blood flow in a cohort of middle-aged adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Higher physiological vulnerability to hypoxic exposure with advancing age in the human brain

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Glutamate levels and perfusion in pons during migraine attacks: A 3T MRI study using proton spectroscopy and arterial spin labeling

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Regional times to equilibria and their impact on semi-quantification of [18F]AV-1451 uptake

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Ictal neck pain investigated in the interictal state - a search for the origin of pain

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Neck pain and headache after whiplash injury: a systematic review and meta-analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Persistent post-traumatic headache attributed to mild traumatic brain injury: Deep phenotyping and treatment patterns

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Plasma Glucose Levels Increase During Spontaneous Attacks of Migraine With and Without Aura

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Dizziness and vertigo during the prodromal phase and headache phase of migraine: A systematic review and meta-analysis

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

Vascular changes during spontaneous headache attacks have been studied over the last 30 years. The interest in cerebral vessels in headache research was initially due to the hypothesis of cerebral vessels as the pain source. Here, we review the knowledge gained by measuring the cerebral vasculature during spontaneous primary headache attacks with the use of single photon emission tomography (SPECT), positron emission tomography (PET), magnetic resonance imaging (MRA) and transcranial Doppler (TCD). Furthermore, the use of near-infrared spectroscopy in headache research is reviewed. Existing TCD studies of migraine and other headache disorders do not provide solid evidence for cerebral blood flow velocity changes during spontaneous attacks of migraine headache. SPECT studies have clearly shown cortical vascular changes following migraine aura and the differences between migraine with aura compared to migraine without aura. PET studies have shown focal activation in brain structures related to headache, but whether the changes are specific to different primary headaches have yet to be demonstrated. MR angiography has shown precise changes in large cerebral vessels during spontaneous migraine without aura attacks. Future development in more precise imaging methods may further elucidate the pathophysiological mechanisms in primary headaches.

Original languageEnglish
JournalJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Volume39
Issue number4
Pages (from-to)633-649
Number of pages17
ISSN0271-678X
DOIs
Publication statusPublished - Apr 2019

    Research areas

  • Journal Article, Neuroimaging, migraine, vascular changes and headache, cortical spreading depression

ID: 52658717