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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Noninvasive Antenatal Screening for Fetal RHD in RhD Negative Women to Guide Targeted Anti-D Prophylaxis

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RhD negative pregnant women who carry an RhD positive fetus are at risk of immunization against the D antigen, which may result in hemolytic disease of the fetus and the newborn. Predicting the fetal RhD status by noninvasive antenatal screening for the fetal RhD gene (RHD) can guide targeted use of antenatal anti-D prophylaxis.Cell-free fetal DNA is extracted from maternal plasma from RhD negative pregnant women at a gestational age of 25 weeks. A real-time PCR-based detection of two RHD exons enables reliable prediction of the fetal RhD status to determine the administration of antenatal prophylaxis, as well as postnatal prophylaxis.

Original languageEnglish
JournalMethods in molecular biology (Clifton, N.J.)
Volume1885
Pages (from-to)347-359
Number of pages13
ISSN1064-3745
DOIs
Publication statusPublished - 2019

    Research areas

  • Anemia, Hemolytic/etiology, Blood Grouping and Crossmatching/methods, Female, Humans, Pregnancy, Prenatal Diagnosis/methods, Real-Time Polymerase Chain Reaction, Rh-Hr Blood-Group System/genetics, Rho(D) Immune Globulin/genetics

ID: 57849819