Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Nonconventional MRI and microstructural cerebral changes in multiple sclerosis

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Calcitonin gene-related peptide - beyond migraine prophylaxis

    Research output: Contribution to journalComment/debateResearchpeer-review

  2. Ageing as a risk factor for neurodegenerative disease

    Research output: Contribution to journalReviewResearchpeer-review

  3. Post-traumatic headache: epidemiology and pathophysiological insights

    Research output: Contribution to journalReviewResearchpeer-review

  4. Does inflammation have a role in migraine?

    Research output: Contribution to journalReviewResearchpeer-review

  5. CGRP as the target of new migraine therapies - successful translation from bench to clinic

    Research output: Contribution to journalReviewResearchpeer-review

  1. Functional-structural assessment of the optic pathways in patients with optic neuritis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Facing privacy in neuroimaging: removing facial features degrades performance of image analysis methods

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Randomized trial of daily high-dose vitamin D3 in patients with RRMS receiving subcutaneous interferon β-1a

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Author response: Nationwide prevalence and incidence study of neuromyelitis optica spectrum disorder in Denmark

    Research output: Contribution to journalComment/debateResearchpeer-review

  5. Treatment escalation leads to fewer relapses compared with switching to another moderately effective therapy

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Christian Enzinger
  • Frederik Barkhof
  • Olga Ciccarelli
  • Massimo Filippi
  • Ludwig Kappos
  • Maria A Rocca
  • Stefan Ropele
  • Àlex Rovira
  • Torben Schneider
  • Nicola de Stefano
  • Hugo Vrenken
  • Claudia Wheeler-Kingshott
  • Jens Wuerfel
  • Franz Fazekas
  • MAGNIMS study group (Jette Lautrup Battistini Frederiksen member)
View graph of relations

MRI has become the most important paraclinical tool for diagnosing and monitoring patients with multiple sclerosis (MS). However, conventional MRI sequences are largely nonspecific in the pathology they reveal, and only provide a limited view of the complex morphological changes associated with MS. Nonconventional MRI techniques, such as magnetization transfer imaging (MTI), diffusion-weighted imaging (DWI) and susceptibility-weighted imaging (SWI) promise to complement existing techniques by revealing more-specific information on microstructural tissue changes. Past years have witnessed dramatic advances in the acquisition and analysis of such imaging data, and numerous studies have used these tools to probe tissue alterations associated with MS. Other MRI-based techniques-such as myelin-water imaging, (23)Na imaging, magnetic resonance elastography and magnetic resonance perfusion imaging-might also shed new light on disease-associated changes. This Review summarizes the rapid technical progress in the use of MRI in patients with MS, with a focus on nonconventional structural MRI. We critically discuss the present utility of nonconventional MRI in MS, and provide an outlook on future applications, including clinical practice. This information should allow appropriate selection of advanced MRI techniques, and facilitate their use in future studies of this disease.

Original languageEnglish
JournalNature reviews. Neurology
Volume11
Issue number12
Pages (from-to)676-86
Number of pages11
ISSN1759-4758
DOIs
Publication statusPublished - Dec 2015

ID: 46031414