Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Nonalcoholic fatty liver disease is an increasing indication for liver transplantation in the Nordic countries

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Pituitary adenylate cyclase-activating peptide: Potential roles in the pathophysiology and complications of cirrhosis

    Research output: Contribution to journalReviewResearchpeer-review

  2. Cardiodynamic state is associated with systemic inflammation and fatal acute-on-chronic liver failure

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. HSD17B13 as a promising therapeutic target against chronic liver disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Non-alcoholic fatty liver disease alters expression of genes governing hepatic nitrogen conversion

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Collagen type IV remodelling gender-specifically predicts mortality in decompensated cirrhosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Peroxisome proliferator-activated receptor activity correlates with poor survival in patients resected for hepatocellular carcinoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Rapid decline in 51Cr-ethylenediaminetetraacetic acid-measured renal function during the first weeks following liver transplantation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Segment 4 occlusion in portal vein embolization increase future liver remnant hypertrophy - A Scandinavian cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND & AIMS: Nonalcoholic fatty liver disease(NAFLD) is the second most common cause of liver transplantation in the US. Data on NAFLD as a liver transplantation indication from countries with lower prevalences of obesity are lacking. We studied the temporal trends of NAFLD as an indication for liver transplantation in the Nordic countries, and compared outcomes for patients with NAFLD to patients with other indications for liver transplantation.

METHOD: Population-based cohort study using data from the Nordic Liver Transplant Registry on adults listed for liver transplantation between 1994 and 2015. NAFLD as the underlying indication for liver transplantation was defined as a listing diagnosis of NAFLD/nonalcoholic steatohepatitis, or cryptogenic cirrhosis with a body mass index ≥25 kg/m2 and absence of other liver diseases. Waiting time for liver transplantation, mortality and withdrawal from the transplant waiting list were registered. Survival after liver transplantation was calculated using multivariable Cox regression, adjusted for age, sex, body mass index and model for end-stage liver disease.

RESULTS: A total of 4609 patients listed for liver transplantation were included. NAFLD as the underlying indication for liver transplantation increased from 2.0% in 1994-1995 to 6.2% in 2011-2015 (P = .01) and was the second most rapidly increasing indication. NAFLD patients had higher age, model for end-stage liver disease and body mass index when listed for liver transplantation, but overall survival after liver transplantation was comparable to non--NAFLD patients (aHR 1.03, 95% CI 0.70-1.53 P = .87).

CONCLUSION: NAFLD is an increasing indication for liver transplantation in the Nordic countries. Despite more advanced liver disease, NAFLD patients have a comparable survival to other patients listed for liver transplantation.

Original languageEnglish
JournalLiver international : official journal of the International Association for the Study of the Liver
Volume38
Issue number11
Pages (from-to)2082-2090
Number of pages9
ISSN1478-3223
DOIs
Publication statusPublished - Nov 2018

ID: 56537599