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Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: Overlapping Mechanisms

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@article{58098454c1f44c3e98e61658c511e884,
title = "Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: Overlapping Mechanisms",
abstract = "Nonalcoholic fatty liver disease (NAFLD) denotes a condition with excess fat in the liver. The prevalence of NAFLD is increasing, averaging > 25% of the Western population. In 25% of the patients, NAFLD progresses to its more severe form: nonalcoholic steatohepatitis and >25% of these progress to cirrhosis following activation of inflammatory and fibrotic processes. NAFLD is associated with obesity, type 2 diabetes, and the metabolic syndrome and represents a considerable and increasing health burden. In the near future, NAFLD cirrhosis is expected to be the most common cause for liver transplantation. NAFLD patients have an increased risk of developing cardiovascular disease as well as liver-related morbidity. In addition, hepatic steatosis itself appears to represent an independent cardiovascular risk factor. In the present review, we provide an overview of the overlapping mechanisms and prevalence of NAFLD and cardiovascular disease.",
keywords = "atherosclerosis, chronic liver diseases, cirrhosis, coronary artery disease, diabetes, nonalcoholic steatohepatitis, obesity",
author = "S{\o}ren M{\o}ller and Thit Kronborg and Nina Kimer and Josephine Grandt and Hove, {Jens Dahlgaard} and Mads Barl{\o}se and Gluud, {Lise Lotte}",
note = "Publisher Copyright: {\textcopyright} 2021 Georg Thieme Verlag. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = aug,
doi = "10.1055/s-0041-1725022",
language = "English",
volume = "41",
pages = "235--247",
journal = "Seminars in Liver Disease",
issn = "0272-8087",
publisher = "Thieme Medical Publishers",
number = "3",

}

RIS

TY - JOUR

T1 - Nonalcoholic Fatty Liver Disease and Cardiovascular Disease

T2 - Overlapping Mechanisms

AU - Møller, Søren

AU - Kronborg, Thit

AU - Kimer, Nina

AU - Grandt, Josephine

AU - Hove, Jens Dahlgaard

AU - Barløse, Mads

AU - Gluud, Lise Lotte

N1 - Publisher Copyright: © 2021 Georg Thieme Verlag. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/8

Y1 - 2021/8

N2 - Nonalcoholic fatty liver disease (NAFLD) denotes a condition with excess fat in the liver. The prevalence of NAFLD is increasing, averaging > 25% of the Western population. In 25% of the patients, NAFLD progresses to its more severe form: nonalcoholic steatohepatitis and >25% of these progress to cirrhosis following activation of inflammatory and fibrotic processes. NAFLD is associated with obesity, type 2 diabetes, and the metabolic syndrome and represents a considerable and increasing health burden. In the near future, NAFLD cirrhosis is expected to be the most common cause for liver transplantation. NAFLD patients have an increased risk of developing cardiovascular disease as well as liver-related morbidity. In addition, hepatic steatosis itself appears to represent an independent cardiovascular risk factor. In the present review, we provide an overview of the overlapping mechanisms and prevalence of NAFLD and cardiovascular disease.

AB - Nonalcoholic fatty liver disease (NAFLD) denotes a condition with excess fat in the liver. The prevalence of NAFLD is increasing, averaging > 25% of the Western population. In 25% of the patients, NAFLD progresses to its more severe form: nonalcoholic steatohepatitis and >25% of these progress to cirrhosis following activation of inflammatory and fibrotic processes. NAFLD is associated with obesity, type 2 diabetes, and the metabolic syndrome and represents a considerable and increasing health burden. In the near future, NAFLD cirrhosis is expected to be the most common cause for liver transplantation. NAFLD patients have an increased risk of developing cardiovascular disease as well as liver-related morbidity. In addition, hepatic steatosis itself appears to represent an independent cardiovascular risk factor. In the present review, we provide an overview of the overlapping mechanisms and prevalence of NAFLD and cardiovascular disease.

KW - atherosclerosis

KW - chronic liver diseases

KW - cirrhosis

KW - coronary artery disease

KW - diabetes

KW - nonalcoholic steatohepatitis

KW - obesity

UR - http://www.scopus.com/inward/record.url?scp=85106496991&partnerID=8YFLogxK

U2 - 10.1055/s-0041-1725022

DO - 10.1055/s-0041-1725022

M3 - Review

C2 - 33992031

VL - 41

SP - 235

EP - 247

JO - Seminars in Liver Disease

JF - Seminars in Liver Disease

SN - 0272-8087

IS - 3

M1 - 1725022

ER -

ID: 65654931