TY - JOUR
T1 - Non-steroidal anti-inflammatory drugs and risk of cardiovascular disease in patients with rheumatoid arthritis
T2 - a nationwide cohort study
AU - Lindhardsen, Jesper
AU - Gislason, Gunnar Hilmar
AU - Jacobsen, Søren
AU - Ahlehoff, Ole
AU - Olsen, Anne-Marie Schjerning
AU - Madsen, Ole Rintek
AU - Torp-Pedersen, Christian
AU - Hansen, Peter Riis
PY - 2014/8
Y1 - 2014/8
N2 - OBJECTIVE: To examine the risk of major cardiovascular disease associated with non-steroidal anti-inflammatory drugs (NSAIDs) in a large 'real-world' contemporary rheumatoid arthritis (RA) cohort. METHODS: A longitudinal cohort study was conducted with use of Danish nationwide individual-level registry data on inpatient and outpatient health care provision, pharmacotherapy and income during 1997-2009. 17 320 RA patients were identified and matched with 69 280 controls (4 : 1) by age and sex. NSAID-associated risk of major cardiovascular disease defined as the combined endpoint of myocardial infarction, stroke or cardiovascular mortality was assessed in multivariable survival models. RESULTS: During follow-up (median 4.9 years) 6283 events occurred. The cardiovascular risk associated with overall NSAID use was significantly lower in RA patients than in controls (HR 1.22 (95% CI 1.09 to 1.37) vs 1.51 (1.36 to 1.66), p
AB - OBJECTIVE: To examine the risk of major cardiovascular disease associated with non-steroidal anti-inflammatory drugs (NSAIDs) in a large 'real-world' contemporary rheumatoid arthritis (RA) cohort. METHODS: A longitudinal cohort study was conducted with use of Danish nationwide individual-level registry data on inpatient and outpatient health care provision, pharmacotherapy and income during 1997-2009. 17 320 RA patients were identified and matched with 69 280 controls (4 : 1) by age and sex. NSAID-associated risk of major cardiovascular disease defined as the combined endpoint of myocardial infarction, stroke or cardiovascular mortality was assessed in multivariable survival models. RESULTS: During follow-up (median 4.9 years) 6283 events occurred. The cardiovascular risk associated with overall NSAID use was significantly lower in RA patients than in controls (HR 1.22 (95% CI 1.09 to 1.37) vs 1.51 (1.36 to 1.66), p
U2 - 10.1136/annrheumdis-2012-203137
DO - 10.1136/annrheumdis-2012-203137
M3 - Journal article
C2 - 23749610
SN - 0003-4967
VL - 73
SP - 1515
EP - 1521
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
ER -