No significant association of the 5' end of neuregulin 1 and schizophrenia in a large Danish sample

Andrés Ingason, Karen Søeby, Sally Timm, August G Wang, Klaus D Jakobsen, Anders Fink-Jensen, Ralf Peter Arnfred Hemmingsen, Henrik Berg Rasmussen, Thomas Werge

20 Citations (Scopus)

Abstract

Neuregulin 1 has been implicated as a susceptibility gene in schizophrenia. Several research groups have reported association with the 5' end of the gene although no causative variant has been reported. We have investigated whether there is association with the 5' end of the gene in Danish schizophrenia patients. We found that the at-risk haplotype initially reported in the Icelandic population was not found in significant excess (or = 1.4, p = 0.12). The haplotype structure in the Danish sample was similar to that of other reported in other Caucasian populations and highly different from that of Chinese.
Original languageEnglish
JournalSchizophrenia Research
Volume83
Issue number1
Pages (from-to)1-5
Number of pages5
ISSN0920-9964
DOIs
Publication statusPublished - 2006

Keywords

  • Case-Control Studies
  • Denmark
  • European Continental Ancestry Group
  • Genetic Predisposition to Disease
  • Haplotypes
  • Humans
  • Nerve Tissue Proteins
  • Neuregulin-1
  • Polymorphism, Single Nucleotide
  • Schizophrenia

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