Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

No neurodevelopmental benefit of cerebral oximetry in the first randomised trial in preterm infants during the first days of life (SafeBoosC II)

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Low-saturated-fat and low-cholesterol diet does not alter pubertal development and hormonal status in adolescents

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Implementation of discharge recommendations in type 1 diabetes depends on specialist nurse follow-up

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Adrenaline and cortisol levels are lower during nighttime than daytime hypoglycaemia in children with type 1 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Retrospective study of paracetamol poisoning in children aged zero to six years found no cases of liver injury

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Exercise-Based Rehabilitation for Heart Failure: Cochrane Systematic Review, Meta-Analysis, and Trial Sequential Analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Neurodevelopmental disorder in children believed to have isolated mild ventriculomegaly prenatally

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Plasma expanders for people with cirrhosis and large ascites treated with abdominal paracentesis

    Research output: Contribution to journalReviewResearchpeer-review

  4. Radix Sophorae flavescentis versus other drugs or herbs for chronic hepatitis B

    Research output: Contribution to journalReviewResearchpeer-review

  5. Social skills training for attention deficit hyperactivity disorder (ADHD) in children aged 5 to 18 years

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

AIM: Cerebral hypoxia has been associated with neurodevelopmental impairment. We studied whether reducing cerebral hypoxia in extremely preterm infants during the first 72 hours of life affected neurological outcomes at two years of corrected age.

METHODS: In 2012-2013 the phase II randomised Safeguarding the Brains of our Smallest Children trial compared visible cerebral near infrared spectroscopy (NIRS) monitoring in an intervention group and blinded NIRS monitoring in a control group. Cerebral hypoxia was significantly reduced in the intervention group. We followed up 115 survivors from eight European centres at two years of corrected age, by conducting a medical examination and assessing their neurodevelopment with the Bayley Scales of Infant and Toddler Development, Second or Third Edition and the parental Ages and Stages Questionnaire, (ASQ).

RESULTS: There were no respective differences between the intervention (n=65) and control (n=50) groups with regard to the mean mental developmental index (89.6 ±19.5 versus 88.4 ±14.7, p=0.77), ASQ score (215 ±58 versus 213 ±58, p=0.88) and the number of children with moderate-to-severe neurodevelopmental impairment (10 versus six, p=0.58).

CONCLUSIONS: Cerebral NIRS monitoring was not associated with long-term benefits or harm with regard to neurodevelopmental outcome at two years of corrected age. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalActa paediatrica
Volume108
Issue number2
Pages (from-to)275-281
ISSN1651-2227
DOIs
Publication statusPublished - 2019

ID: 54639653