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No Islet Cell Hyperfunction, but Altered Gut-Islet Regulation and Postprandial Hypoglycemia in Glucose-Tolerant Patients 3 Years After Gastric Bypass Surgery

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  1. Different malabsorptive obesity surgery interventions result in distinct postprandial amino acid metabolomic signatures

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  2. A Low Dose of Pasireotide Prevents Hypoglycemia in Roux-en-Y Gastric Bypass-Operated Individuals

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  3. Evidence for Relationship Between Early Dumping and Postprandial Hypoglycemia After Roux-en-Y Gastric Bypass

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  4. Gastric bypass with different biliopancreatic limb lengths results in similar post-absorptive metabolomics profiles

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  1. The renal extraction and the natriuretic action of GLP-1 in humans depend on interaction with the GLP-1 receptor

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  2. Fractionated free fatty acids and their relation to diabetes status after Roux-en-Y gastric bypass: A cohort study

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  3. Multidisciplinær håndtering af svær jernforgiftning som følge af suicidalforsøg

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Postprandial hyperinsulinemia characterizes Roux-en-Y gastric bypass (RYGB) and sometimes leads to reactive hypoglycemia. We prospectively evaluated changes in beta cell function in seven RYGB-operated patients with a median follow-up of 2.9 years with hyperglycemic clamps and oral glucose tolerance tests (OGTTs). Three years after RYGB, weight loss was 26 % and insulin sensitivity had improved. Insulin secretion during clamp experiments was largely unchanged compared to before surgery. In contrast, insulin secretion in response to the OGTTs doubled when evaluated by the disposition index and 2-h plasma glucose declined to a mean of 3.3 ± 0.3 mmol/l postoperatively. Our findings indicate that intrinsic beta cell function remains unchanged in glucose-tolerant patients even years after RYGB, while altered gut-islet regulation drive risk of postprandial hyperinsulinemic hypoglycemia.

Original languageEnglish
JournalObesity Surgery
Volume26
Issue number9
Pages (from-to)2263-7
Number of pages5
ISSN0960-8923
DOIs
Publication statusPublished - Nov 2016

    Research areas

  • Journal Article

ID: 49150144