Abstract
The impact of transcranial pulsed magnetic stimulation on blood-brain barrier permeability was studied in rats. An integral uptake technique was used to asses the blood-brain barrier permeability to the tracers [3H]sucrose, [14C]urea, and 36Cl-. From the arterial plasma concentration-time curve-integral the permeability surface-area products were calculated. A Dantec magnetic stimulator delivering a peak magnetic field of 1.9 T with a rise-time of 160 microseconds was used for transcranial stimulation of the rats. One group of rats had about 50-60 stimulations during the 15-min infusion of the tracers while another group was exposed to 50 magnetic stimulations a day for one week. A third group comprised the controls. No differences in permeability surface-area product were found for any of the three tracers in the rats exposed to magnetic stimulation as compared with the controls. It is concluded that with regard to blood-barrier integrity, pulsed magnetic stimulation of the brain can be regarded as safe.
| Original language | English |
|---|---|
| Journal | Neuroscience |
| Volume | 38 |
| Issue number | 1 |
| Pages (from-to) | 277-80 |
| Number of pages | 4 |
| ISSN | 0306-4522 |
| DOIs | |
| Publication status | Published - 1990 |
| Externally published | Yes |
Keywords
- Animals
- Blood-Brain Barrier
- Capillary Permeability
- Electromagnetic Phenomena/methods
- Male
- Physical Stimulation
- Rats
- Rats, Inbred Strains
Fingerprint
Dive into the research topics of 'No effect of pulsed magnetic stimulation on the blood-brain barrier in rats'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS