No effect of oral contraceptives on the metabolism of levetiracetam

Anne Sabers; Jacob Christensen

doi:10.1016/j.eplepsyres.2011.04.001

No effect of oral contraceptives on the metabolism of levetiracetam

Anne Sabers, Jacob Christensen

Department of Neurology

9 Citations (Scopus)

Abstract

The effect on clearance of levetiracetam (LEV) was estimated in women with epilepsy of childbearing potential using oral contraceptives (OCs). The estimated clearance (plasma concentration/daily dose) was 39 nmol/L/mg (range 14-88 nmol/L/mg) among women who did not use OC (n=30) and 38 nmol/L/mg (range 18-103 nmol/L/mg) among OC users (n=23) (p=0.8). In conclusion, combing LEV and OCs seems safe from a pharmacokinetic perspective.

Original language	English
Journal	Epilepsy Research
Volume	95
Issue number	3
Pages (from-to)	277-9
Number of pages	3
ISSN	0920-1211
DOIs	https://doi.org/10.1016/j.eplepsyres.2011.04.001
Publication status	Published - 2011

Keywords

Adolescent
Adult
Anticonvulsants
Contraceptives, Oral
Dose-Response Relationship, Drug
Epilepsy
Female
Humans
Middle Aged
Piracetam
Pregnancy
Young Adult

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10.1016/j.eplepsyres.2011.04.001

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title = "No effect of oral contraceptives on the metabolism of levetiracetam",

abstract = "The effect on clearance of levetiracetam (LEV) was estimated in women with epilepsy of childbearing potential using oral contraceptives (OCs). The estimated clearance (plasma concentration/daily dose) was 39 nmol/L/mg (range 14-88 nmol/L/mg) among women who did not use OC (n=30) and 38 nmol/L/mg (range 18-103 nmol/L/mg) among OC users (n=23) (p=0.8). In conclusion, combing LEV and OCs seems safe from a pharmacokinetic perspective.",

keywords = "Adolescent, Adult, Anticonvulsants, Contraceptives, Oral, Dose-Response Relationship, Drug, Epilepsy, Female, Humans, Middle Aged, Piracetam, Pregnancy, Young Adult",

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year = "2011",

doi = "10.1016/j.eplepsyres.2011.04.001",

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pages = "277--9",

journal = "Epilepsy Research",

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T1 - No effect of oral contraceptives on the metabolism of levetiracetam

AU - Sabers, Anne

AU - Christensen, Jacob

PY - 2011

Y1 - 2011

N2 - The effect on clearance of levetiracetam (LEV) was estimated in women with epilepsy of childbearing potential using oral contraceptives (OCs). The estimated clearance (plasma concentration/daily dose) was 39 nmol/L/mg (range 14-88 nmol/L/mg) among women who did not use OC (n=30) and 38 nmol/L/mg (range 18-103 nmol/L/mg) among OC users (n=23) (p=0.8). In conclusion, combing LEV and OCs seems safe from a pharmacokinetic perspective.

AB - The effect on clearance of levetiracetam (LEV) was estimated in women with epilepsy of childbearing potential using oral contraceptives (OCs). The estimated clearance (plasma concentration/daily dose) was 39 nmol/L/mg (range 14-88 nmol/L/mg) among women who did not use OC (n=30) and 38 nmol/L/mg (range 18-103 nmol/L/mg) among OC users (n=23) (p=0.8). In conclusion, combing LEV and OCs seems safe from a pharmacokinetic perspective.

KW - Adolescent

KW - Adult

KW - Anticonvulsants

KW - Contraceptives, Oral

KW - Dose-Response Relationship, Drug

KW - Epilepsy

KW - Female

KW - Humans

KW - Middle Aged

KW - Piracetam

KW - Pregnancy

KW - Young Adult

U2 - 10.1016/j.eplepsyres.2011.04.001

DO - 10.1016/j.eplepsyres.2011.04.001

M3 - Journal article

C2 - 21549563

SN - 0920-1211

VL - 95

SP - 277

EP - 279

JO - Epilepsy Research

JF - Epilepsy Research

IS - 3

ER -

No effect of oral contraceptives on the metabolism of levetiracetam

Abstract

Keywords

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