No effect of growth hormone administration on substrate oxidation during exercise in young, lean men

Mette Hansen, Rikke Morthorst, Benny Larsson, Rolf Dall, Allan Flyvbjerg, Michael Højby Rasmussen, Hans Orskov, Michael Kjaer, Kai Henrik Wiborg Lange

24 Citations (Scopus)

Abstract

The purpose of this study was to examine the effects of increased fat availability induced by growth hormone (GH) administration on the oxidative metabolism during exercise. Seven well-trained males (age 25 +/- 2 years (mean +/- S.E.M.); peak oxygen consumption : 62 +/- 1 ml min(-1) kg(-1) (completed four randomised trials: 120 min bicycling at 55% 4 h after receiving either 7.5 IU (2.5 mg) GH or placebo (Plc), and during rest after receiving either GH or Plc. In all studies a standardized meal was given 2 h after GH or Plc injection. GH administration resulted in an approximately 60-fold increase in serum GH concentration at rest (P < 0.0001) and during exercise (P < 0.0001). The increase in serum GH was followed by an increase in circulating glycerol at rest (8%, P < 0.0001). When combined with exercise the increase in plasma glycerol was more pronounced (GH: 716% of baseline versus Plc: 328%, P < 0.0001). However, this increase in fat mobilization did not increase fat oxidation during exercise (indirect calorimetry). In conclusion, GH administration combined with aerobic exercise increased lipolytic parameters substantially more than exercise alone, but did not further augment whole body fat oxidation.

Original languageEnglish
JournalThe Journal of physiology
Volume567
Issue numberPt 3
Pages (from-to)1035-45
Number of pages11
ISSN0022-3751
DOIs
Publication statusPublished - 15 Sept 2005

Keywords

  • Adipose Tissue
  • Adolescent
  • Adult
  • Blood Glucose
  • Carbohydrate Metabolism
  • Cross-Over Studies
  • Double-Blind Method
  • Exercise
  • Fatty Acids, Nonesterified
  • Glycerol
  • Human Growth Hormone
  • Humans
  • Lactic Acid
  • Male
  • Oxidation-Reduction
  • Clinical Trial
  • Journal Article
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

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