Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

No effect of angiotensin II AT(2)-receptor antagonist PD 123319 on cerebral blood flow autoregulation

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Intradural artery dilation during experimentally induced migraine attacks

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Transcranial low-frequency pulsating electromagnetic fields (T-PEMF) as post-concussion syndrome treatment

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Blood pressure and brain injury in cardiac surgery: a secondary analysis of a randomized trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Cigarette smoking and cerebral blood flow in a cohort of middle-aged adults

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Blockade of the renin-angiotensin system with angiotensin-converting enzyme inhibitors (ACE-I) or angiotensin AT1-receptor antagonists shift the limits of autoregulation of cerebral blood flow (CBF) towards lower blood pressure (BP). The role of AT2-receptors in the regulation of the cerebral circulation is uncertain. Hence, the present study investigated the effect on CBF autoregulation of blocking of angiotensin AT2-receptors with PD 123319 in spontaneously hypertensive rats (SHR). Anaesthetised and ventilated SHR were given PD 123319, 0.36 mg/kg/min, intravenously, and compared with a control group. CBF was measured by the intracarotid 133xenon injection method and BP was raised by noradrenaline infusion and lowered by controlled haemorrhage in separate groups of rats. The limits of autoregulation were determined by computed least-sum-of-squares analysis. PD 123319 did not influence baseline CBF, but resulted in a minor BP decrease (10 control and 10 treated rats). The lower limit of CBF autoregulation (eight treated and eight control) as well as the upper limit of CBF autoregulation (eight treated and eight control) were not significantly different in PD 123319 and control animals (lower limit treated 102+/-4 mmHg and control 94+/-4; NS, and upper limit treated 171 +/- 10 mmHg and control 162+/-7; NS). These findings indicate that acute AT2-receptor blockade does not influence CBF autoregularion.
Original languageEnglish
JournalJournal of the renin-angiotensin-aldosterone system : JRAAS
Volume2
Issue number3
Pages (from-to)188-92
Number of pages4
ISSN1470-3203
DOIs
Publication statusPublished - 2001

    Research areas

  • Angiotensin Receptor Antagonists, Animals, Blood Pressure, Cerebrovascular Circulation, Homeostasis, Hypertension, Imidazoles, Male, Pyridines, Rats, Rats, Inbred SHR, Receptor, Angiotensin, Type 2, Time Factors

ID: 32535447