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No donor age effect of human serum on collagen synthesis signaling and cell proliferation of human tendon fibroblasts

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  1. Maintenance of muscle strength following a one-year resistance training program in older adults

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  3. Associations between shoulder symptoms and concomitant pathology in patients with traumatic supraspinatus tears

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  4. The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

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  5. Early development of tendinopathy in humans: Sequence of pathological changes in structure and tissue turnover signaling

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The aging process of tendon tissue is associated with decreased collagen content and increased risk for injuries. An essential factor in tendon physiology is transforming growth factor-β1 (TGF-β1), which is presumed to be reduced systemically with advanced age. The aim of this study was to investigate whether human serum from elderly donors would have an inhibiting effect on the expression of collagen and collagen-related genes as well as on cell proliferative capacity in tendon cells from young individuals. There was no difference in systemic TGF-β1 levels in serum obtained from young and elderly donors, and we found no difference in collagen expression when cells were subjected to human serum from elderly versus young donors. In addition, tendon cell proliferation was similar when culture medium was supplemented with serum of different donor age. These findings suggest that factors such as the cell intrinsic capacity or the tissue-specific environment rather than systemic circulating factors are important for functional capacity throughout life in human tendon cells.
Original languageEnglish
JournalMechanisms of Ageing and Development
Volume133
Issue number5
Pages (from-to)246-54
Number of pages9
ISSN0047-6374
DOIs
Publication statusPublished - 2012

    Research areas

  • Adolescent, Adult, Aged, Aging, Cell Proliferation, Cells, Cultured, Collagen, Fibroblasts, Humans, Male, Middle Aged, Serum, Signal Transduction, Tendons, Transforming Growth Factor beta1, Young Adult

ID: 36612307