No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [123I]PE2I

G Thomsen; M Ziebell; Peter Steen Jensen; Sofi da Cunha-Bang; G M Knudsen; L H Pinborg

doi:10.1002/oby.20225

No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [123I]PE2I

G Thomsen, M Ziebell, Peter Steen Jensen, Sofi da Cunha-Bang, G M Knudsen, L H Pinborg

35 Citations (Scopus)

Abstract

Dopamine plays an important role in both the rewarding and conditioning effects of food. These effects involve mesolimbic, mesocortical, and nigrostriatal pathways. In humans, the most consistent finding has been reduced striatal dopamine D2/3 receptor availability. In striatum, dopamine is inactivated by reuptake via the dopamine transporter (DAT). The aim of the study was to test the hypothesis of lower DAT availability in obese healthy subjects using a selective DAT radiotracer in a sample of subjects with a wide range of BMI values.

Original language	English
Journal	Obesity (Silver Spring, Md.)
Volume	21
Issue number	9
Pages (from-to)	1803-6
Number of pages	4
ISSN	1930-7381
DOIs	https://doi.org/10.1002/oby.20225
Publication status	Published - Sept 2013

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title = "No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [123I]PE2I",

abstract = "Dopamine plays an important role in both the rewarding and conditioning effects of food. These effects involve mesolimbic, mesocortical, and nigrostriatal pathways. In humans, the most consistent finding has been reduced striatal dopamine D2/3 receptor availability. In striatum, dopamine is inactivated by reuptake via the dopamine transporter (DAT). The aim of the study was to test the hypothesis of lower DAT availability in obese healthy subjects using a selective DAT radiotracer in a sample of subjects with a wide range of BMI values.",

author = "G Thomsen and M Ziebell and Jensen, {Peter Steen} and {da Cunha-Bang}, Sofi and Knudsen, {G M} and Pinborg, {L H}",

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AU - Thomsen, G

AU - Ziebell, M

AU - Jensen, Peter Steen

AU - da Cunha-Bang, Sofi

AU - Knudsen, G M

AU - Pinborg, L H

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AB - Dopamine plays an important role in both the rewarding and conditioning effects of food. These effects involve mesolimbic, mesocortical, and nigrostriatal pathways. In humans, the most consistent finding has been reduced striatal dopamine D2/3 receptor availability. In striatum, dopamine is inactivated by reuptake via the dopamine transporter (DAT). The aim of the study was to test the hypothesis of lower DAT availability in obese healthy subjects using a selective DAT radiotracer in a sample of subjects with a wide range of BMI values.

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DO - 10.1002/oby.20225

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No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [123I]PE2I

Abstract

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