Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

No Contribution of GAD-65 and IA-2 Autoantibodies around Time of Diagnosis to the Increasing Incidence of Juvenile Type 1 Diabetes: A 9-Year Nationwide Danish Study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Osteoporosis Is Associated with Deteriorating Clinical Status in Adults with Cystic Fibrosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Anti-Müllerian Hormone and Its Clinical Use in Pediatrics with Special Emphasis on Disorders of Sex Development

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Normal sweat secretion despite impaired growth hormone-insulin-like growth factor-I axis in obese subjects

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Characterization of plasma lipidomics in adolescent subjects with increased risk for type 1 diabetes in the DiPiS cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Systemic TNFα correlates with residual β-cell function in children and adolescents newly diagnosed with type 1 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Cost of Treating Skin Problems in Patients with Diabetes who Use Insulin Pumps and/or Glucose Sensors

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Circulating Inflammatory Markers Are Inversely Associated with Heart Rate Variability Measures in Type 1 Diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Aims. A new perspective on autoantibodies as pivotal players in the pathogenesis of type 1 diabetes (T1D) has recently emerged. Our key objective was to examine whether increased levels of autoantibodies against the β-cell autoantigens glutamic acid decarboxylase (isoform 65) (GADA) and insulinoma associated antigen-2A (IA-2A) mirrored the 3.4% annual increase in incidence of T1D. Methods. From the Danish Childhood Diabetes Register, we randomly selected 500 patients and 500 siblings for GADA and IA-2A analysis (1997 through 2005). Blood samples were taken within three months after onset. A robust log-normal regression model was used. Nine hundred children and adolescents had complete records and were included in the analysis. Cochran-Armitage test for trend was used to evaluate changes in prevalence of autoantibody positivity by period. Results. No significant changes in levels of GADA and IA-2A were found over our 9-year study period. No trends in autoantibody positivity-in either patients or siblings-were found. Levels of GADA and IA-2A were significantly associated with HLA risk groups and GADA with age. Conclusion. The prevalence of positivity and the levels of GADA and IA-2A have not changed between 1997 and 2005 in newly diagnosed patients with T1D and their siblings without T1D.

Original languageEnglish
Article number8350158
JournalInternational Journal of Endocrinology
Volume2016
Number of pages7
ISSN1687-8337
DOIs
Publication statusPublished - 2016

ID: 49833234