No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population

C Lindberg; P Koefoed; E S Hansen; T G Bolwig; J F Rehfeld; E Mellerup; O S Jørgensen; L V Kessing; T Werge; S Haugbøl; A G Wang; D P D Woldbye

doi:10.1111/j.1600-0447.2005.00648.x

No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population

C Lindberg, P Koefoed, E S Hansen, T G Bolwig, J F Rehfeld, E Mellerup, O S Jørgensen, L V Kessing, T Werge, S Haugbøl, A G Wang, D P D Woldbye

26 Citations (Scopus)

Abstract

OBJECTIVE: A polymorphism in the promoter region of the NPY gene at position -399 C > T was recently reported to be associated with schizophrenia in a Japanese population and with treatment refractory unipolar depression in a Swedish population. The objective of this study was to investigate potential associations between the polymorphism and three psychiatric disorders in a Danish population.

METHOD: We investigated the occurrence of the polymorphism in patients with schizophrenia (n = 291), unipolar depression (n = 256) and panic disorder (n = 142) compared with controls (n = 716).

RESULTS: We detected the polymorphism -399 C > T at a frequency of 48% in controls. No significant differences were found between genotype or allele frequencies in controls vs. the patient groups.

CONCLUSION: The lack of association between the -399 C > T polymorphism and schizophrenia, unipolar depression or panic disorder, respectively, suggests that the polymorphism is not involved in the etiology of these disorders in the Danish population.

Original language	English
Journal	Acta Psychiatrica Scandinavica
Volume	113
Issue number	1
Pages (from-to)	54-8
Number of pages	5
ISSN	0001-690X
DOIs	https://doi.org/10.1111/j.1600-0447.2005.00648.x
Publication status	Published - Jan 2006

Keywords

Adult
Aged
Aged, 80 and over
Alleles
DNA Primers
Denmark
Depressive Disorder
Female
Gene Frequency
Genotype
Humans
Incidence
Male
Middle Aged
Neuropeptide Y
Panic Disorder
Polymerase Chain Reaction
Polymorphism, Genetic
Prevalence
Schizophrenia
Journal Article
Research Support, Non-U.S. Gov't

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Lindberg, C., Koefoed, P., Hansen, E. S., Bolwig, T. G., Rehfeld, J. F., Mellerup, E., Jørgensen, O. S., Kessing, L. V., Werge, T., Haugbøl, S., Wang, A. G., & Woldbye, D. P. D. (2006). No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population. Acta Psychiatrica Scandinavica, 113(1), 54-8. https://doi.org/10.1111/j.1600-0447.2005.00648.x

Lindberg, C, Koefoed, P, Hansen, ES, Bolwig, TG, Rehfeld, JF, Mellerup, E, Jørgensen, OS, Kessing, LV , Werge, T, Haugbøl, S, Wang, AG & Woldbye, DPD 2006, 'No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population', Acta Psychiatrica Scandinavica, vol. 113, no. 1, pp. 54-8. https://doi.org/10.1111/j.1600-0447.2005.00648.x

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abstract = "OBJECTIVE: A polymorphism in the promoter region of the NPY gene at position -399 C > T was recently reported to be associated with schizophrenia in a Japanese population and with treatment refractory unipolar depression in a Swedish population. The objective of this study was to investigate potential associations between the polymorphism and three psychiatric disorders in a Danish population.METHOD: We investigated the occurrence of the polymorphism in patients with schizophrenia (n = 291), unipolar depression (n = 256) and panic disorder (n = 142) compared with controls (n = 716).RESULTS: We detected the polymorphism -399 C > T at a frequency of 48\% in controls. No significant differences were found between genotype or allele frequencies in controls vs. the patient groups.CONCLUSION: The lack of association between the -399 C > T polymorphism and schizophrenia, unipolar depression or panic disorder, respectively, suggests that the polymorphism is not involved in the etiology of these disorders in the Danish population.",

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AU - Lindberg, C

AU - Koefoed, P

AU - Hansen, E S

AU - Bolwig, T G

AU - Rehfeld, J F

AU - Mellerup, E

AU - Jørgensen, O S

AU - Kessing, L V

AU - Werge, T

AU - Haugbøl, S

AU - Wang, A G

AU - Woldbye, D P D

PY - 2006/1

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N2 - OBJECTIVE: A polymorphism in the promoter region of the NPY gene at position -399 C > T was recently reported to be associated with schizophrenia in a Japanese population and with treatment refractory unipolar depression in a Swedish population. The objective of this study was to investigate potential associations between the polymorphism and three psychiatric disorders in a Danish population.METHOD: We investigated the occurrence of the polymorphism in patients with schizophrenia (n = 291), unipolar depression (n = 256) and panic disorder (n = 142) compared with controls (n = 716).RESULTS: We detected the polymorphism -399 C > T at a frequency of 48% in controls. No significant differences were found between genotype or allele frequencies in controls vs. the patient groups.CONCLUSION: The lack of association between the -399 C > T polymorphism and schizophrenia, unipolar depression or panic disorder, respectively, suggests that the polymorphism is not involved in the etiology of these disorders in the Danish population.

AB - OBJECTIVE: A polymorphism in the promoter region of the NPY gene at position -399 C > T was recently reported to be associated with schizophrenia in a Japanese population and with treatment refractory unipolar depression in a Swedish population. The objective of this study was to investigate potential associations between the polymorphism and three psychiatric disorders in a Danish population.METHOD: We investigated the occurrence of the polymorphism in patients with schizophrenia (n = 291), unipolar depression (n = 256) and panic disorder (n = 142) compared with controls (n = 716).RESULTS: We detected the polymorphism -399 C > T at a frequency of 48% in controls. No significant differences were found between genotype or allele frequencies in controls vs. the patient groups.CONCLUSION: The lack of association between the -399 C > T polymorphism and schizophrenia, unipolar depression or panic disorder, respectively, suggests that the polymorphism is not involved in the etiology of these disorders in the Danish population.

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No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population

Abstract

Keywords

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