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No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population

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@article{3bf48cc8f7b44803967845f9799ef8b3,
title = "No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population",
abstract = "OBJECTIVE: A polymorphism in the promoter region of the NPY gene at position -399 C > T was recently reported to be associated with schizophrenia in a Japanese population and with treatment refractory unipolar depression in a Swedish population. The objective of this study was to investigate potential associations between the polymorphism and three psychiatric disorders in a Danish population.METHOD: We investigated the occurrence of the polymorphism in patients with schizophrenia (n = 291), unipolar depression (n = 256) and panic disorder (n = 142) compared with controls (n = 716).RESULTS: We detected the polymorphism -399 C > T at a frequency of 48{\%} in controls. No significant differences were found between genotype or allele frequencies in controls vs. the patient groups.CONCLUSION: The lack of association between the -399 C > T polymorphism and schizophrenia, unipolar depression or panic disorder, respectively, suggests that the polymorphism is not involved in the etiology of these disorders in the Danish population.",
keywords = "Adult, Aged, Aged, 80 and over, Alleles, DNA Primers, Denmark, Depressive Disorder, Female, Gene Frequency, Genotype, Humans, Incidence, Male, Middle Aged, Neuropeptide Y, Panic Disorder, Polymerase Chain Reaction, Polymorphism, Genetic, Prevalence, Schizophrenia, Journal Article, Research Support, Non-U.S. Gov't",
author = "C Lindberg and P Koefoed and Hansen, {E S} and Bolwig, {T G} and Rehfeld, {J F} and E Mellerup and J{\o}rgensen, {O S} and Kessing, {L V} and T Werge and S Haugb{\o}l and Wang, {A G} and Woldbye, {D P D}",
year = "2006",
month = "1",
doi = "10.1111/j.1600-0447.2005.00648.x",
language = "English",
volume = "113",
pages = "54--8",
journal = "Acta Psychiatrica Scandinavica",
issn = "0001-690X",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population

AU - Lindberg, C

AU - Koefoed, P

AU - Hansen, E S

AU - Bolwig, T G

AU - Rehfeld, J F

AU - Mellerup, E

AU - Jørgensen, O S

AU - Kessing, L V

AU - Werge, T

AU - Haugbøl, S

AU - Wang, A G

AU - Woldbye, D P D

PY - 2006/1

Y1 - 2006/1

N2 - OBJECTIVE: A polymorphism in the promoter region of the NPY gene at position -399 C > T was recently reported to be associated with schizophrenia in a Japanese population and with treatment refractory unipolar depression in a Swedish population. The objective of this study was to investigate potential associations between the polymorphism and three psychiatric disorders in a Danish population.METHOD: We investigated the occurrence of the polymorphism in patients with schizophrenia (n = 291), unipolar depression (n = 256) and panic disorder (n = 142) compared with controls (n = 716).RESULTS: We detected the polymorphism -399 C > T at a frequency of 48% in controls. No significant differences were found between genotype or allele frequencies in controls vs. the patient groups.CONCLUSION: The lack of association between the -399 C > T polymorphism and schizophrenia, unipolar depression or panic disorder, respectively, suggests that the polymorphism is not involved in the etiology of these disorders in the Danish population.

AB - OBJECTIVE: A polymorphism in the promoter region of the NPY gene at position -399 C > T was recently reported to be associated with schizophrenia in a Japanese population and with treatment refractory unipolar depression in a Swedish population. The objective of this study was to investigate potential associations between the polymorphism and three psychiatric disorders in a Danish population.METHOD: We investigated the occurrence of the polymorphism in patients with schizophrenia (n = 291), unipolar depression (n = 256) and panic disorder (n = 142) compared with controls (n = 716).RESULTS: We detected the polymorphism -399 C > T at a frequency of 48% in controls. No significant differences were found between genotype or allele frequencies in controls vs. the patient groups.CONCLUSION: The lack of association between the -399 C > T polymorphism and schizophrenia, unipolar depression or panic disorder, respectively, suggests that the polymorphism is not involved in the etiology of these disorders in the Danish population.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Alleles

KW - DNA Primers

KW - Denmark

KW - Depressive Disorder

KW - Female

KW - Gene Frequency

KW - Genotype

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Neuropeptide Y

KW - Panic Disorder

KW - Polymerase Chain Reaction

KW - Polymorphism, Genetic

KW - Prevalence

KW - Schizophrenia

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1111/j.1600-0447.2005.00648.x

DO - 10.1111/j.1600-0447.2005.00648.x

M3 - Journal article

VL - 113

SP - 54

EP - 58

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

SN - 0001-690X

IS - 1

ER -

ID: 53562120