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No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population

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OBJECTIVE: A polymorphism in the promoter region of the NPY gene at position -399 C > T was recently reported to be associated with schizophrenia in a Japanese population and with treatment refractory unipolar depression in a Swedish population. The objective of this study was to investigate potential associations between the polymorphism and three psychiatric disorders in a Danish population.

METHOD: We investigated the occurrence of the polymorphism in patients with schizophrenia (n = 291), unipolar depression (n = 256) and panic disorder (n = 142) compared with controls (n = 716).

RESULTS: We detected the polymorphism -399 C > T at a frequency of 48% in controls. No significant differences were found between genotype or allele frequencies in controls vs. the patient groups.

CONCLUSION: The lack of association between the -399 C > T polymorphism and schizophrenia, unipolar depression or panic disorder, respectively, suggests that the polymorphism is not involved in the etiology of these disorders in the Danish population.

Original languageEnglish
JournalActa Psychiatrica Scandinavica
Volume113
Issue number1
Pages (from-to)54-8
Number of pages5
ISSN0001-690X
DOIs
Publication statusPublished - Jan 2006

    Research areas

  • Adult, Aged, Aged, 80 and over, Alleles, DNA Primers, Denmark, Depressive Disorder, Female, Gene Frequency, Genotype, Humans, Incidence, Male, Middle Aged, Neuropeptide Y, Panic Disorder, Polymerase Chain Reaction, Polymorphism, Genetic, Prevalence, Schizophrenia, Journal Article, Research Support, Non-U.S. Gov't

ID: 53562120